Tractography: where do we go from here?
Tractography: where do we go from here?
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DOI：
10.1089/brain.2011.0033
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发表时间：
2011
影响因子：
3.4
通讯作者：
Johansen-Berg H
中科院分区：
文献类型：
--
作者：
Jbabdi S;Johansen-Berg H
弥散纤维束成像为人脑解剖学的研究提供了巨大的潜力。然而，作为一种研究大脑连接的方法，纤维束成像具有局限性，因为它是间接的，不准确的，难以量化。尽管有这些局限性，纤维束成像的适当使用可以是解决某些问题的有力手段。此外，虽然纤维束成像的一些限制是根本性的，但其他限制可以通过方法和技术的进步来缓解。本文概述了弥散磁共振纤维束成像方法，重点是未来的进展可能如何解决测量大脑连接的挑战。这篇综述的部分内容有些挑衅性，希望它们可以引发讨论，可能缺乏一个领域，在这个领域中，方法的明显简单性（与功能磁共振成像同行相比）可能隐藏一些基本问题，最终阻碍了对结果的解释，并对纤维束描记术真正能教我们什么人类大脑解剖学产生怀疑。
Diffusion tractography offers enormous potential for the study of human brain anatomy. However, as a method to study brain connectivity, tractography suffers from limitations, as it is indirect, inaccurate, and difficult to quantify. Despite these limitations, appropriate use of tractography can be a powerful means to address certain questions. In addition, while some of tractography’s limitations are fundamental, others could be alleviated by methodological and technological advances. This article provides an overview of diffusion MR tractography methods with a focus on how future advances might address challenges in measuring brain connectivity. Parts of this review are somewhat provocative, in the hope that they may trigger discussions possibly lacking in a field where the apparent simplicity of the methods (compared to their FMRI counterparts) can hide some fundamental issues that ultimately hinder the interpretation of findings, and cast doubt as to what tractography can really teach us about human brain anatomy.