Claudins in intestines: Distribution and functional significance in health and diseases.
Claudins in intestines: Distribution and functional significance in health and diseases.
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DOI：
10.4161/tisb.24978
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发表时间：
2013-07-01
期刊：
影响因子：
3.1
通讯作者：
Chen YH
中科院分区：
文献类型：
--
作者：
Lu Z;Ding L;Lu Q;Chen YH
肠道不仅是消化食物和吸收营养物质的器官，而且还提供防御屏障以抵抗摄入的病原体和有毒物质。紧密连接（TJs）是连接复合体的最顶端组分，提供肠上皮细胞中细胞-细胞粘附的一种形式，并且在调节细胞旁屏障通透性中起关键作用。TJ的改变导致许多病理生理疾病，引起营养吸收不良和肠道结构破坏，甚至可能导致全身器官衰竭。紧密连接蛋白是TJ的主要结构和功能组分，在哺乳动物中至少有24个成员。紧密连接蛋白具有独特的电荷选择性，通过收紧细胞旁途径或作为细胞旁通道发挥作用，调节通过细胞旁途径的离子和小分子。本文综述了claudin家族成员的功能、在哺乳动物肠道的分布和定位、claudin在肠道相关疾病中的改变、claudin表达和定位的调控因子以及对肠道通透性的影响，为肠道疾病的治疗提供了新的思路。
Intestines are organs that not only digest food and absorb nutrients, but also provide a defense barrier against pathogens and noxious agents ingested. Tight junctions (TJs) are the most apical component of the junctional complex, providing one form of cell-cell adhesion in enterocytes and playing a critical role in regulating paracellular barrier permeability. Alteration of TJs leads to a number of pathophysiological diseases causing malabsorption of nutrition and intestinal structure disruption, which may even contribute to systemic organ failure. Claudins are the major structural and functional components of TJs with at least 24 members in mammals. Claudins have distinct charge-selectivity, either by tightening the paracellular pathway or functioning as paracellular channels, regulating ions and small molecules passing through the paracellular pathway. In this review, we have discussed the functions of claudin family members, their distribution and localization in the intestinal tract of mammals, their alterations in intestine-related diseases and chemicals/agents that regulate the expression and localization of claudins as well as the intestinal permeability, which provide a therapeutic view for treating intestinal diseases.