Relationships Among T-Helper Cell Subtypes, Cytokines, and Traditional Chinese Medicine Syndromes in Patients with Psoriasis
Relationships Among T-Helper Cell Subtypes, Cytokines, and Traditional Chinese Medicine Syndromes in Patients with Psoriasis
复制标题
银屑病患者辅助T细胞亚型、细胞因子与中医证候的关系
DOI：
10.1166/jmihi.2017.1984
复制
发表时间：
2017-02
影响因子：
--
通讯作者：
Li L. L.
中科院分区：
文献类型：
--
作者：
Sun S. S.;Duan X. W.;Chen X.;Zhang R. T.;Chai L. M.;Li L. L.
目的探讨寻常型银屑病患者外周血中辅助性T细胞亚群、干扰素-γ、白介素4、肿瘤坏死因子-α、白介素22与3种中医证型之间的关系。方法对寻常型银屑病患者(血热证、血瘀证、血燥证)及健康体检者外周血中Th1、Th2、Th17、Th22细胞及干扰素-γ、IL-4、Th22水平进行检测。结果血瘀证和血瘀证患者外周血中α的比例明显高于正常对照组。此外，BHS组明显高于BDS组。血瘀证和血瘀证患者的Inf-γ比值显著高于健康对照组。血瘀证患者的BSS显著高于血瘀证患者。血瘀证、血瘀证、血瘀证患者外周血中Th2、IL-4比值均显著低于健康对照组。血瘀证和血瘀证患者Th1 7、肿瘤坏死因子-α比值均显著高于健康对照组。血瘀证组和血瘀证组Th17细胞比例明显高于血瘀证组。Th22在血瘀证和血瘀证患者中的比例显著高于健康人和血瘀证患者。IL-22水平在银屑病患者中明显高于健康对照组，且BHS患者的IL-22水平明显高于BSS患者。结论银屑病患者不同中医证型的T辅助细胞亚群比例存在实质性差异，有助于了解银屑病的临床病理特点。
ObjectiveWe investigated the relationships among T-helper cell subtypes, interferon (INF)-γ, interleukin (IL)-4, tumor necrosis factor (TNF)-α, IL-22 and three traditional Chinese medicine (TCM) syndromes in patients with psoriasis vulgaris.MethodsMedical records of patients with psoriasis vulgaris (with different TCM types: bloodheat syndrome (BHS), blood-stasis syndrome (BSS), and blood-dryness syndrome (BDS)), and healthy individuals were examined to compare peripheral blood Th1, Th2, Th17, and Th22 cells and levels of INF-γ, IL-4, TNF-α and IL-22.ResultsIn patients with BHS and BSS, the Th1 ratio was significantly higher than that in healthy controls. Moreover, that in patients with BHS was significantly higher than that in patients with BDS. INF-γ ratio was significantly higher in individuals with BHS and BSS than in healthy controls. And that with BDS, BSS were significantly higher than that with BDS. The Th2, IL-4 ratios in patients with BHS, BSS, and BDS were significantly lower than those in health controls. The Th17, TNF-α ratios were significantly higher in individuals with BHS and BSS than in healthy controls. As well the Th17 ratio with BHS and BSS were significantly higher than that with BDS. Th22 ratio was significantly higher in individuals with BHS and BDS than in healthy individuals and individuals with BSS. IL-22 levels were significantly higher in these individuals than in healthy controls, and higher levels were observed in patients with BHS than in patients with BSS.ConclusionSubstantial variations in T-helper cell subtype ratios were observed in patients with psoriasis with different TCM syndromes, providing insights into the clinicopathological features of psoriasis.