The effects of chronic metabolic acidosis on patterns of protein synthesis in rat renal cortex.

The effects of chronic metabolic acidosis on patterns of protein synthesis in rat renal cortex.
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慢性代谢性酸中毒对大鼠肾皮质蛋白质合成模式的影响。

DOI:
10.1016/0305-0491(84)90012-9
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发表时间:
1984
期刊:
Comparative biochemistry and physiology. B, Comparative biochemistry
影响因子:
--
通讯作者:
Simpson,DP
Simpson,DP
中科院分区:
--
文献类型:
--
作者:
Haas,MJ;Simpson,DP

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在大鼠慢性代谢性酸中毒增加净合成的17个肾皮质蛋白质的数量范围从1.5到4.5倍。这些蛋白质的分子量在13,000和42,000之间,等电点在大约5.5和7.0之间。在酸中毒动物的肾皮质样品中未检测到正常动物中不存在的新蛋白质。三种蛋白质在慢性代谢性酸中毒中的净合成率显著降低。根据它们的物理性质和酸中毒时净合成率的类似变化,这些蛋白质中的一些似乎是密切相关的,并且可能在大鼠肾脏中协调表达。
In the rat chronic metabolic acidosis increases the net synthesis of 17 renal cortex proteins by amounts ranging from 1.5 to 4.5-fold. These proteins have molecular weights between 13,000 and 42,000 and isoelectric points between approximately 5.5 and 7.0. No new proteins not also present in normal animals are detected in renal cortex samples from acidotic animals. Three proteins undergo substantial reductions in their net synthetic rates in chronic metabolic acidosis. On the basis of their physical properties and similar alterations in net synthetic rate in acidosis some of these proteins appear to be closely related and may be coordinately expressed in the rat kidney.
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