The use of neuropathic pain drugs in children with sickle cell disease is associated with older age, female sex, and longer length of hospital stay.
The use of neuropathic pain drugs in children with sickle cell disease is associated with older age, female sex, and longer length of hospital stay.
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DOI：
10.1097/mph.0000000000000265
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发表时间：
2015-01
期刊：
影响因子：
--
通讯作者：
Panepinto JA
中科院分区：
文献类型：
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作者：
Brandow AM;Farley RA;Dasgupta M;Hoffmann RG;Panepinto JA
尽管神经性疼痛在镰状细胞病（SCD）中越来越被认识到，但神经性疼痛药物如何用于SCD儿童尚不清楚。因此，我们调查了这些药物的使用，并假设年龄较大和女性与神经性药物使用增加相关，并且这些药物的使用与住院时间较长相关。我们分析了儿科健康信息系统（2004-09），包括所有0-18岁的住院患者就诊的任何SCD相关（所有基因型）出院诊断。为了限制混杂因素，我们排除了精神病和癫痫发作访视。抗癫痫药、三环类抗抑郁药和选择性5-羟色胺再摄取抑制剂是研究药物。广义估计方程确定了年龄和性别对神经性药物使用的影响以及神经性药物使用对住院时间的影响。我们分析了53，557次访视; 2.9%接受了≥1种神经病药物。接受神经性药物的几率随着年龄[参考组0-4岁：5-10，OR 5.7; 11-14，OR 12.5; 15-18，OR 22.8;所有p<0.0001]和女性性别[OR 1.5; p=0.001]而显著增加。使用神经性药物与住院时间延长相关[RR 8.3; p<0.0001]。SCD儿童神经性药物的使用与年龄较大、女性和住院时间较长相关。
Although neuropathic pain is increasingly recognized in sickle cell disease (SCD), it is unknown how neuropathic pain drugs are used in children with SCD. Thus, we investigated use of these drugs and hypothesized older age and female gender are associated with increased neuropathic drug use and the use of these drugs is associated with longer length of stay. We analyzed the Pediatric Health Information System (2004-09) including all inpatient visits 0-18 years with any SCD-related (all genotypes) discharge diagnosis. To limit confounding we excluded psychiatric and seizure visits. Antiepileptics, tricyclic antidepressants, and selective serotonin reuptake inhibitors were drugs of interest. Generalized Estimating Equations determined the impact of age and gender on neuropathic drug use and the impact of neuropathic drug use on length of stay. We analyzed 53,557 visits; 2.9% received ≥1 neuropathic drugs. The odds of receiving a neuropathic drug increased significantly with age [Reference group 0-4 yrs: 5-10, OR 5.7; 11-14, OR 12.5; 15-18, OR 22.8; all p<0.0001] and female gender [OR 1.5; p=0.001)]. Neuropathic drug use was associated with longer length of stay [RR 8.3; p<0.0001]. Neuropathic drug use in children with SCD was associated with older age, female gender, and longer length of stay.