Post-exposure administration of edaravone attenuates noise-induced hearing loss
Post-exposure administration of edaravone attenuates noise-induced hearing loss
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DOI：
10.1016/j.ejphar.2005.08.026
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发表时间：
2005-10-17
影响因子：
5
通讯作者：
Yamashita, H
中科院分区：
文献类型：
--
作者：
Tanaka, K;Takemoto, T;Yamashita, H
我们研究了抗氧化剂依达拉奉对豚鼠声损伤的影响。依达拉奉（1.722 × 10（-2）M）通过渗透泵注入右耳，左耳未处理作为对照。动物在暴露于130 dB噪声前9 h（-9 h组，n=7）和暴露于130 dB噪声3 h后9 h（+9 h组，n=8）、21 h（+21 h组，n=7）和33 h（+33 h组，n=4）接受依达拉奉。噪声暴露后7天，我们检查了听觉脑干反应阈值和感觉上皮组织病理学特征的变化。在+9 h组中观察到听性脑干反应阈值的最小偏移和外毛细胞缺失的最小比例。这一结果得到了4-羟基-2-壬烯醛免疫组化分析的支持。我们的数据表明，依达拉奉在治疗声损伤方面可能具有临床有效性，尤其是在噪声暴露后21小时内给予。(c)2005 Elsevier B. V.保留所有权利。
We investigated the effects of the antioxidant edaravone against acoustic trauma in guinea pigs. Edaravone (1.722 x 10(-2) M) was infused into the right ear by an osmotic pump, and the left ear was untreated for control. Animals received edaravone 9 h before (-9 h group, n=7) and 9 h (+9 h group, n=8), 21 h (+21 h group, n=7) and 33 h (+33 h group, n=4) after 3-h exposure to 130-dB noise. Seven days after noise exposure, we examined the shift in auditory brainstem response thresholds and histopathologic characteristics of the sensory epithelia. The smallest shift in auditory brainstem response threshold and smallest proportion of missing outer hair cells were observed in the +9 h group. This result was supported by immunohistochemical analysis of 4-hydroxy-2-nonenal. Our data suggest that edaravone may be clinically effective in the treatment of acoustic trauma, especially if given within 21 h of noise exposure. (c) 2005 Elsevier B.V. All rights reserved.