Characteristics of the Mucosal Surface on Scanning Electron Microscopy in Patients with Remitting Ulcerative Colitis
Characteristics of the Mucosal Surface on Scanning Electron Microscopy in Patients with Remitting Ulcerative Colitis
复制标题
缓解型溃疡性结肠炎患者黏膜表面扫描电镜特征
DOI：
10.1007/s10620-020-06609-4
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Kanai T.
中科院分区：
文献类型：
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作者：
Nomura E;Sujino T;Hosoe N;Yoshimatsu Y;Tanemoto S;Takabayashi K;Mutaguchi M;Shimoda M;Naganuma M;Ogata H;Kanai T.
背景溃疡性结肠炎（Ulcerative Colitis，UC）是一种以慢性肠上皮损伤为特征的疾病，以往的研究对活动期UC患者的肠上皮结构进行了电镜观察，目的本研究旨在通过扫描电镜观察UC患者的肠上皮结构，并探讨缓解期UC患者的特征。并从盲肠和直肠收集结肠组织样品。然后，我们比较了上皮表面结构的扫描电镜UC患者谁是在临床缓解和健康controls.ResultsIn健康对照组，结肠表面包括小叶（称为单位），一个隐窝位于每个单位的中间。在UC患者中，我们发现不规则的单位和隐窝口大小，双隐窝征（每个单位> 1个隐窝），以及肠上皮细胞中的小泡数量较少。与健康对照组相比，UC患者直肠内单位大小不规则，双隐窝征，隐窝口大小不规则。UC患者中的小泡出现频率较低，比健康controls.ConclusionsSEM显示了一个独特的上皮结构在UC患者谁是在缓解。
BackgroundUlcerative colitis (UC) is characterized by chronic intestinal epithelial damage, and previous studies have evaluated the epithelial structure of patients with active UC using electron microscopy.AimsThis study aimed to assess the intestinal epithelial structure using scanning electron microscopy (SEM) and the features of patients with UC who are in remission.MethodsIn total, eight healthy controls and 20 patients with UC were enrolled, and colonic tissue samples from the cecum and rectum were collected. Then, we compared the epithelial surface structure on SEM between patients with UC who are in clinical remission and healthy controls.ResultsIn healthy controls, the colonic surface comprises small lobes (termed units), with one crypt located in the middle of each unit. In patients with UC, we found irregular unit and crypt mouth size, double crypt sign (> 1 crypt per unit), and lower number of small vesicles in the intestinal epithelial cells. Compared with healthy controls, patients with UC often presented with irregular unit size, double crypt sign, and irregular crypt mouth size in the rectum. The small vesicles were observed less frequently in patients with UC than in healthy controls.ConclusionsSEM revealed a unique epithelial structure in patients with UC who are in remission.