Scanning electron and light microscopic observations on the healing process after sintered bone implantation in rats.
Scanning electron and light microscopic observations on the healing process after sintered bone implantation in rats.
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扫描电子和光学显微镜观察大鼠烧结骨植入后愈合过程。
DOI：
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发表时间：
1995
影响因子：
2
通讯作者：
K. Tsuyama
中科院分区：
文献类型：
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作者：
Mikio Matsuda;S. Kita;Masanori Takekawa;S. Ohtsubo;K. Tsuyama
用扫描电子显微镜和光学显微镜比较了烧结骨和人工合成羟基磷灰石在大鼠顶骨内植入后的愈合过程。结果表明，烧结型天然骨与人工合成羟基磷灰石植入材料之间的差异在于骨结合状态和植入材料的生物可吸收率，尽管两者含有相同的羟基磷灰石。烧结骨植入后1~2周，新生骨侵入材料内。5周时硬脑膜侧烧结骨表面已完全被新骨覆盖。值得注意的是，在2周时，烧结骨表面出现了以Howship‘s陷窝为特征的骨吸收区域，材料被新骨取代。光学显微镜显示新骨侵入并发育成烧结骨，支持扫描电子显微镜观察。在人工合成的羟基磷灰石中，新骨与材料粘连紧密，就像烧结骨植入一样。新骨没有侵入人工合成的羟基磷灰石。没有证据表明羟基磷灰石有吸收作用。这表明，烧结骨的自然和生物结构为植入后的液体循环和植入提供了有利的环境。
The healing process after implantation of sintered bone in the rat parietal bone was compared with that of synthetic hydroxyapatite using both scanning electron and light microscopy. The results showed that the differences between the sintered natural bone and the synthetic hydroxyapatite implantations were in the states of bone union and the bioresorbability of the implanted materials, even though both materials consist of the same hydroxyapatite. In the sintered bone implantation, the newly formed bone invaded into the material at 1 to 2 weeks after implantation. The sintered bone surface on the dura mater side was completely covered by the new bone at 5 weeks. It is noteworthy that bone resorbing areas characterized by Howship's lacunae were observed on the sintered bone surface at 2 weeks and the material was replaced by new bone. Light microscopy, which revealed the invasion and the development of the new bone into the sintered bone, supported the scanning electron microscopic observations. In the synthetic hydroxyapatite, the new bone adhered closely to the material just like the sintered bone implantation. The new bone did not invade into the synthetic hydroxyapatite. There was no evidence of the resorption of the hydroxyapatite. This shows that the natural and the biological structures of the sintered bone offer an advantageous environment to fluid circulation and ingrowth after implantation.