Palladium-Catalyzed Synthesis of 2-Substituted Benzothiazoles via a C-H Functionalization/Intramolecular C-S Bond Formation Process
Palladium-Catalyzed Synthesis of 2-Substituted Benzothiazoles via a C-H Functionalization/Intramolecular C-S Bond Formation Process
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DOI：
10.1021/ol802033p
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发表时间：
2008-11-20
期刊：
影响因子：
5.2
通讯作者：
Doi, Takayuki
中科院分区：
文献类型：
--
作者：
Inamoto, Kiyofumi;Hasegawa, Chisa;Doi, Takayuki
以硫代苯甲酰苯胺为原料，在钯催化剂存在下，通过C-H官能化/C-S键形成，催化合成了2-取代苯并噻唑。该方法的特征在于使用由10摩尔%的Pd（II）、50摩尔%的Cu（I）和2当量的Bu 4 NBr组成的新型催化体系，该催化体系以高产率产生具有良好官能团耐受性的各种取代的苯并噻唑。
Catalytic synthesis of 2-substituted benzothiazoles from thiobenzanilides was achieved in the presence of a palladium catalyst through C-H functionalization/C-S bond formation. This method features the use of a novel catalytic system consisting of 10 mol % of Pd(II), 50 mol % of Cu(I), and 2 equiv of Bu4NBr that produced variously substituted benzothiazoles in high yields with good functional group tolerance.