Cerebral regions associated with verbal response initiation, suppression and strategy use
Cerebral regions associated with verbal response initiation, suppression and strategy use
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DOI：
10.1016/s0028-3932(00)00026-9
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发表时间：
2000-01-01
期刊：
影响因子：
2.6
通讯作者：
Bullmore, ET
中科院分区：
文献类型：
--
作者：
de Zubicaray, GI;Zelaya, FO;Bullmore, ET
用功能磁共振成像（fMRI）研究了在两种条件下完成一项新任务时的脑激活。在反应启动条件下，被试指定一系列范例（具体名词）中的每一个所属的一般从属范畴。在反应抑制条件下，受试者被要求指定一个一般的上位范畴Co，每个样本不属于，与指示，他们是不是提名同一类别的反应连续两次。这两种条件产生不同的模式激活相对于关节控制条件采用相同的刺激。当直接比较启动和抑制条件时，反应抑制在右侧额极、眶额皮质和前扣带回、左侧背外侧前额叶皮质和后扣带回以及两侧楔前叶、视觉联合皮质和小脑产生激活，反应潜伏期在抑制条件下显著延长。两个广泛定义的策略与彗星生产的话在抑制条件下是一个自排序的选择从上级类别中确定的第一部分的任务和新的类别反应的产生。神经解剖学相关的反应启动，抑制和战略的使用进行了讨论，是各自的作用，反应抑制和战略的产生。(C)2000爱思唯尔科技有限公司版权所有。
Cerebral activation associated with performance on a novel task involving two conditions was investigated with functional magnetic resonance imaging (fMRI), In the response initiation condition, subjects nominated the general subordinate category to which each of a series of exemplars (concrete nouns) belonged. In the response suppression condition, subjects were required to nominate a general superordinate category Co which each exemplar did not belong, with the instruction that they a ere not to nominate the same category response twice in a row. Both conditions produced distinct patterns of activation relative to an articulation control condition employing identical stimuli. When initiation and suppression conditions were directly compared, response suppression produced activation in the right frontal pole, orbital frontal cortex and anterior cingulate, left dorsolateral prefrontal cortex and posterior cingulate, and bilaterally in the precuneus, visual association cortex and cerebellum Response latencies were significantly longer in the suppression condition. Two broadly-defined strategies associated with the comet production of words during the suppression condition were a self-ordered selection from among the superordinate categories identified during the first section of the task and the generation of novel category responses. The neuroanatomical correlates of response initiation, suppression and strategy use are discussed, as are the respective roles of response suppression and strategy generation. (C) 2000 Elsevier Science Ltd. All rights reserved.