MULTIPLE FORMS OF SYRINGOMYCIN
MULTIPLE FORMS OF SYRINGOMYCIN
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DOI：
10.1016/0885-5765(88)90014-8
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发表时间：
1988-11-01
影响因子：
2.7
通讯作者：
SURICO, G
中科院分区：
文献类型：
--
作者：
BALLIO, A;BARRA, D;SURICO, G
从三株假单胞菌pv.根据已公布的方法，已显示阿铃蟾含有一组结构上相关的肽，其可通过HPLC在反相柱上解析。在水解产物中，丝氨酸、苯丙氨酸、2，4-二氨基丁酸和精氨酸的摩尔比为2：1：2：1，占FAB质谱测定分子量的近50%。 未分级制剂的大部分抗生素活性在有限数量的峰中恢复。
Preparations of syringomycin purified from three isolates of Pseudomonas syringae pv. syringae according to published procedures have been shown to contain a group of structurally related peptides which can be resolved by HPLC on a reverse phase column. In the acid hydrolysate of all components serine, phenylalanine, 2,4-diaminobutyric acid and arginine in the ratio 2:1:2:1 have been found. These products account for nearly 50% of the molecular weights determined by FAB mass spectrometry. Most of the antibiotic activity of the unfractionated preparations is recovered in a limited number of peaks.