The impact of irritable bowel syndrome on health-related quality of life
The impact of irritable bowel syndrome on health-related quality of life
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DOI：
10.1053/gast.2000.16484
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发表时间：
2000-09-01
期刊：
影响因子：
29.4
通讯作者：
Mayer, EA
中科院分区：
文献类型：
--
作者：
Gralnek, IM;Hays, RD;Mayer, EA
背景与目的：目前评价肠易激综合征(IBS)患者健康相关生活质量(HRQOL)的数据很少，我们利用已报道的美国普通人群和部分慢性病患者的HRQOL数据，对IBS对HRQOL的影响进行了评估和比较。方法：使用SF-36健康调查，我们将877名IBS患者的HRQOL与之前报道的美国普通人群以及胃食道反流病(GERD)、糖尿病、抑郁症和依赖透析的终末期肾病(ESRD)患者的SF-36数据进行比较。结果：在全部8个SF-36量表中，肠易激综合征患者的生存质量明显低于美国普通人群(P<；0.001)。与胃肠道反流病患者相比，肠易激综合征患者在除身体功能外的所有SF-36量表上的得分均显著降低(P<；0.001)。类似地，IBS患者在选定的SF-36量表上的HRQOL显著低于糖尿病和终末期肾病患者。肠易激综合征患者的SF-36量表心理健康评分显著高于抑郁症患者(P<；0.001)。结论：肠易激综合征患者存在明显的生活质量损害。HRQOL的下降在精力/疲劳、身体健康问题造成的角色限制、身体疼痛和一般健康观念方面最为明显。这些数据进一步洞察了IBS对患者功能状态和幸福感的影响。
Background & Aims: Few data are available to evaluate health-related quality of life (HRQOL) of people with irritable bower syndrome (IBS), We evaluated and compared the impact of IBS on HRQOL using previously reported HRQOL data for the U.S. general population and for people with selected chronic diseases. Methods: Using the SF-36 Health Survey, we compared the HRQOL of IBS patients (n = 877) with previously reported SF-36 data for the general U.S. population and for patients with gastroesophageal reflux disease (GERD), diabetes mellitus, depression, and dialysis-dependent end-stage renal disease (ESRD). Results: On all 8 SF-36 scales, IBS patients had significantly worse HRQOL than the U.S. general population (P < 0.001). Compared with GERD patients, IBS patients scored significantly lower on all SF-36 scales (P < 0.001) except physical functioning. Similarly, IBS patients had significantly worse HRQOL on selected SF-36 scales than patients with diabetes mellitus and ESRD. IBS patients had significantly better mental health SF-36 scale scores than patients with depression (P < 0.001), Conclusions: IBS patients experience significant impairment in HRQOL. Decrements in HRQOL are most pronounced in energy/fatigue, role limitations caused by physical health problems, bodily pain, and general health perceptions. These data offer further insight into the impact of IBS on patient functional status and well-being.