Fruit and vegetable intake and risk of cancer: a prospective cohort study
Fruit and vegetable intake and risk of cancer: a prospective cohort study
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DOI：
10.3945/ajcn.2008.26722
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发表时间：
2009-01-01
影响因子：
7.1
通讯作者：
Subar, Amy F.
中科院分区：
文献类型：
--
作者：
George, Stephanie M.;Park, Yikyung;Subar, Amy F.
背景：有可能的证据表明，某些类型的水果和蔬菜可以预防多种癌症。目的：我们假设，在50岁的女性和男性中，水果和蔬菜的摄入量与总癌症发病率呈负相关。设计：我们在美国国立卫生研究院的队列中进行了一项前瞻性研究--美国退休人员协会饮食和健康研究。我们将My金字塔当量数据库(版本1.0)与食物频率调查问卷数据合并，以计算水果和蔬菜的杯当量。从1995年到2003年，我们分别在195,229名女性和288,109名男性中确认了15,792例和35,071例癌症病例。结果：水果摄入量与总癌症风险无关(女性RRQ5(Vs)(Q1)=0.99；95%CI：0.94，1.0 5；P趋势=0.059)或男性(RRQ5(Vs)(Q1)=0.98；95%CI：0.95，1.0 2；P趋势=0.17)。在女性中，蔬菜摄入量与总癌症风险无关(RRQ5(Vs)(Q1)=1.0 4；95%CI：0.98，1.09；趋势分析为P=0.084)，但与男性的风险显著降低有关(RRQ5(Vs)(Q1)=0.94；95%CI：0.91，0.97；P趋势=0.004)。当我们将分析限于从不吸烟的男性时，这一重大发现在男性中不再明显(RRQ5vsQ10.97；95%CI：0.91vs1.04；趋势=0.474)。结论：在这一队列中，水果和蔬菜的摄入量与总癌症发病率基本无关。吸烟的残留混杂可能是观察到的与男性蔬菜摄入量负相关的一个解释。2009年美国临床杂志；：347-53。
Background: There is probable evidence that some types of fruit and vegetables provide protection against many cancers.Objective: We hypothesized that fruit and vegetable intakes are inversely related to the incidence of total cancers among women and men aged >50 y.Design: We performed a prospective study among the cohort of the National Institutes of Health-AARP Diet and Health Study. We merged the MyPyramid Equivalents Database (version 1.0) with food-frequency-questionnaire data to calculate cup equivalents for fruit and vegetables. From 1995 to 2003, we identified 15,792 and 35,071 cancer cases in 195,229 women and 288,109 men, respectively. We used Cox proportional hazards models to estimate multivariate relative risks (RRs) and 95% CIs associated with the highest compared with the lowest quintile (Q) of fruit and vegetable intakes.Results: Fruit intake was not associated with the risk of total cancer among women (RRQ5 (vs) (Q1) = 0.99; 95% CI: 0.94, 1.05; P trend = 0.059) or men (RRQ5 (vs) (Q1) = 0.98; 95% CI: 0.95, 1.02; P for trend = 0.17). Vegetable intake was not associated with risk of total cancer among women (RRQ5 (vs) (Q1) = 1.04; 95% CI: 0.98, 1.09; P for trend = 0.084), but was associated with a significant decrease in risk in men (RRQ5 (vs) (Q1) = 0.94; 95% CI: 0.91, 0.97; P trend = 0.004). This significant finding among men was no longer evident when we limited the analysis to men who never smoked (RRQ5 vs Q1 0.97; 95% CI: 0.91, 1.04; P for trend = 0.474).Conclusions: Intake of fruit and vegetables was generally unrelated to total cancer incidence in this cohort. Residual confounding by smoking is a likely explanation for the observed inverse association with vegetable intake among men. Am J Clin Nutr 2009; 89: 347-53.