Microfabricated porous layer open tubular (PLOT) column.
Microfabricated porous layer open tubular (PLOT) column.
复制标题
DOI：
10.1039/c9lc00886a
复制
发表时间：
2019-11
期刊：
影响因子：
6.1
通讯作者：
M. W. Li;Jinyan She;Hongbo Zhu;Ziqi Li;Xudong Fan
中科院分区：
文献类型：
--
作者：
M. W. Li;Jinyan She;Hongbo Zhu;Ziqi Li;Xudong Fan
微气相色谱法（μGC）的发展旨在快速和原位分析挥发性有机化合物（VOCs）用于环境保护、工业监测和毒理学。然而，由于缺乏合适的微柱和相应的固定相，目前的μGC无法分离高挥发性化学物质，如甲烷、甲醇和甲醛，这些化学物质因其高毒性和致癌性而备受关注。这种无能极大地限制了μGC字段的适用性。为了解决这一缺陷，本文报道了以二乙烯基苯为固定相的微制备多孔层开管（μPLOT）柱的研制和表征。μPLOT色谱柱的分离能力通过对轻烷烃、甲醛溶液和有机溶剂的三种不同分析得到证明，显示了其对各种高挥发性化合物的通用实用性。进一步的表征表明μPLOT柱在高湿度和高温（高达300°C）下的稳定性能。μPLOT色谱柱占地面积小，具有分离高挥发性化学物质的能力，因此非常适合集成到μGC系统中，从而显着扩大了μGC在快速现场分析VOCs方面的适用性。
Development of micro gas chromatography (μGC) is aimed at rapid and in situ analysis of volatile organic compounds (VOCs) for environmental protection, industrial monitoring, and toxicology. However, due to the lack of appropriate microcolumns and associated stationary phases, current μGC is unable to separate highly volatile chemicals such as methane, methanol, and formaldehyde, which are of great interest for their high toxicity and carcinogenicity. This inability has significantly limited μGC field applicability. To address this deficiency, this paper reports the development and characterization of a microfabricated porous layer open tubular (μPLOT) column with a divinylbenzene-based stationary phase. The separation capabilities of the μPLOT column are demonstrated by three distinct analyses of light alkanes, formaldehyde solution, and organic solvents, exhibiting its general utility for a wide range of highly volatile compounds. Further characterization shows the robust performance of the μPLOT column in the presence of high moisture and at high temperatures (up to 300 °C). The small footprint and the ability to separate highly volatile chemicals make the μPLOT column highly suitable for integration into μGC systems, thus significantly broadening μGC's applicability to rapid, field analysis of VOCs.