Pleural effusion as an indicator for the poor prognosis of COVID-19 patients
Pleural effusion as an indicator for the poor prognosis of COVID-19 patients
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胸腔积液作为COVID-19患者预后不良的指标
DOI：
10.1111/ijcp.14123
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发表时间：
2021-03-16
影响因子：
2.6
通讯作者：
Zhou, Qiong
中科院分区：
文献类型：
--
作者：
Wei, Xiao-Shan;Wang, Xu;Zhou, Qiong
背景：冠状病毒病19(新冠肺炎)是一个全球性的健康问题，在过去的几个月里已经成为一种大流行。目的了解新冠肺炎胸腔积液患者的临床表现。方法对华中科技大学同济医学院协和医院收治的新冠肺炎胸腔积液患者进行回顾性调查。患者的咽拭子用实时聚合酶链式反应进行检测。根据入院时有无胸腔积液的CT扫描，新冠肺炎患者被分为两组。结果胸腔积液发生率为9.19%。有胸腔积液的患者更有可能是重症或危重病例。此外，有胸腔积液的患者死亡率增加。在799名出院病人中，与没有胸腔积液的病人相比，有胸腔积液的病人自出现症状以来的住院时间和病毒排出时间较长。出院后，217名患者前往协和医院进行后续CT复查。CT扫描显示有胸腔积液的患者在新冠肺炎发病后肺部炎症消退的时间较无胸腔积液的患者长。结论这一人群需要特别关注，胸腔积液可能是新冠肺炎患者预后不良的一个指标。
Background Coronavirus Disease 19 (COVID-19) is a global health concern that has become a pandemic over the past few months. This study aims at understanding the clinical manifestations of COVID-19 patients with pleural effusion.Methods COVID-19 patients were retrospectively enrolled from the Union Hospital, Tongji Medical College, Huazhong University of Science and Technology. Pharyngeal swabs from patients were tested using real-time polymerase chain reaction. Patients with COVID-19 were divided into two groups based on their computed tomography (CT) scans for the presence of pleural effusion at admission. We compared the clinical features, laboratory findings, scans and clinical outcomes between the two groups.Results Pleural effusion was observed in 9.19% of the patients. Patients with pleural effusion were more likely to be severe or critical cases. Moreover, patients with pleural effusion were associated with increased mortality. Of the 799 discharged patients, patients with pleural effusion had longer hospital stays and duration of viral shedding since the onset of symptoms as compared with that for patients without pleural effusion. After discharge, 217 patients visited for a follow-up CT re-examination at the Union Hospital. The CT scans showed that patients with pleural effusion required a longer time to resolve the lung inflammation after the onset of COVID-19 as compared with the time required by patients without pleural effusion.Conclusion This population of patients requires special attention and pleural effusion may be an indicator of poor prognosis in COVID-19 patients.