Insomnia, Health-Related Quality of Life and Health Outcomes in Children: A Seven Year Longitudinal Cohort
Insomnia, Health-Related Quality of Life and Health Outcomes in Children: A Seven Year Longitudinal Cohort
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DOI：
10.1038/srep27921
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发表时间：
2016-06-13
影响因子：
4.6
通讯作者：
Parthasarathy, Sairam
中科院分区：
文献类型：
--
作者：
Combs, Daniel;Goodwin, James L.;Parthasarathy, Sairam
抑郁症在儿童中很常见，并且与学校表现下降和精神病理学增加有关。虽然成人失眠与健康相关生活质量（HRQOL）恶化有关，但评估儿童失眠和HRQOL的数据不足。我们对194名儿童（96名女孩，研究开始时年龄为8.7 ± 1.6岁，数据分析时年龄为15.0 ± 1.8岁）的纵向队列进行了7年的HRQOL和失眠的健康相关性研究。根据国际睡眠障碍分类第二版（ICSD 2），27%的儿童出现间歇性失眠，4%的儿童持续失眠。报告ICSD 2衍生失眠的儿童HRQOL较低。此外，失眠的存在与报告新疾病的风险增加相关（间歇性失眠比值比5.9 [95% CI 1.3-26.7，p = 0.04]，持续性失眠比值比8 [95% CI 2.3-27.7，p = 0.001]）。持续性ICSD 2衍生失眠与报告新药物（比值比4.9（95% CI 1.0-23.6），p = 0.049）和报告新精神病药物（比值比13.7，95% CI：2.6-73.5，p = 0.002）的风险增加相关。即使在调整了社会经济因素和阻塞性睡眠呼吸暂停的存在之后，这些关联仍然存在。儿童的营养不良与HRQOL和健康结局恶化相关。
Insomnia is common in children, and is associated with decreased school performance and increased psychopathology. Although adult insomnia is linked to worsened health-related quality of life (HRQOL), there is insufficient data evaluating insomnia and HRQOL in children. We examined the HRQOL and health associations of insomnia in a longitudinal cohort of 194 children (96 girls, age at study start 8.7 +/- 1.6 years, age at data analysis 15.0 +/- 1.8 years) over 7 years. International Classification of Sleep Disorders, second edition (ICSD2) derived insomnia was seen intermittently in 27% of children, and was persistent in 4%. Children reporting ICSD2-derived insomnia had lower HRQOL. Additionally, the presence of insomnia was associated with an increased risk of reporting a new medical condition (intermittent insomnia odds ratio 5.9 [95% CI 1.3-26.7, p = 0.04], persistent insomnia odds ratio 8 [95% CI 2.3-27.7, p = 0.001]). Persistent ICSD2-derived insomnia was associated with an increased risk of reporting a new medication (odds ratio 4.9 (95% CI 1.0-23.6), p = 0.049), and reporting a new psychiatric medication (odds ratio 13.7, 95% CI: 2.6-73.5, p = 0.002). These associations were present even after adjusting for socioeconomic factors and the presence of obstructive sleep apnea. Insomnia in children is associated with worsened HRQOL and health outcomes.