Molecular analysis of the genome of Chuzan virus, a member of the Palyam serogroup viruses, and its phylogenetic relationships to other orbiviruses
Molecular analysis of the genome of Chuzan virus, a member of the Palyam serogroup viruses, and its phylogenetic relationships to other orbiviruses
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DOI：
10.1099/0022-1317-80-4-937
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发表时间：
1999-04-01
影响因子：
3.8
通讯作者：
Furuuchi, S
中科院分区：
文献类型：
--
作者：
Yamakawa, M;Kubo, M;Furuuchi, S
楚赞病毒属于Palyam血清群环状病毒，引起牛的先天性畸形，其全基因组核苷酸序列已通过编码次要核心蛋白(VP1、VP4和VP6)和非结构蛋白(NS1、NS2和NS3)的基因分析完成。楚赞病毒基因组全长18915个碱基对，开放阅读框编码量为6071aa，与环状病毒其他血清组的比较序列分析表明，环状病毒的中和抗原VP2变异最大，主要核心蛋白VP3最保守。总体而言，环状病毒中除VP2外的结构蛋白比非结构蛋白保守。楚赞病毒与非洲马病病毒的亲缘关系最近。
The nucleotide sequence of the entire genome of Chuzan virus, which belongs to the Palyam serogroup orbiviruses and causes congenital abnormalities of cattle, has been completed by analysis of the genes encoding minor core proteins (VP1, VP4 and VP6) and non-structural proteins (NS1, NS2 and NS3). The genome of Chuzan virus is 18915 bp in length and the coding capacity of its open reading frames is 6071 aa, Comparative sequence analysis with other serogroups of the genus Orbivirus indicated that the outer capsid protein VP2, which is the neutralizing antigen, appears to be the most variable and the major core protein VP3 is the most conserved, Overall, the structural proteins, with the exception of VP2, are more conserved than the non-structural proteins among orbiviruses. Chuzan virus is phylogenetically most related to African horsesickness virus.