Albendazole therapy for subarachnoid cysticerci: Clinical and neuroimaging analysis of 17 patients
Albendazole therapy for subarachnoid cysticerci: Clinical and neuroimaging analysis of 17 patients
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DOI：
10.1136/jnnp.62.6.659
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发表时间：
1997-06-01
影响因子：
11
通讯作者：
DelBrutto, OH
中科院分区：
文献类型：
--
作者：
DelBrutto, OH
17例蛛网膜下腔囊尾蚴病患者接受阿苯达唑15 mg/kg/d治疗8 d。所有患者在试验期间也接受了皮质类固醇。治疗反应的评价包括治疗前和治疗后3个月CT显示的囊肿数量的比较，以及试验前后患者临床状态的评价。治疗前17例患者有30个蛛网膜下腔囊尾蚴，其中11个直径> 50 mm。位于大脑半球凸面17个，侧裂7个，环池5个，桥小脑角池1个。14例患者出现癫痫发作，10例出现轻偏瘫，3例出现痴呆，1例出现视力下降，1例出现面肌痉挛。治疗后获得的脑CT显示27个囊肿消退（90%有效率）。14例（82%）患者的所有囊肿均完全消退。除3名患者外，其余患者均无症状。其余缺陷包括轻偏瘫在两名患者和视力下降在一个。结论阿苯达唑是治疗蛛网膜下腔囊尾蚴病的有效药物，它能使CT上大部分病灶消失，并能明显改善患者的临床表现。
Seventeen patients with subarachnoid cysticerci received albendazole at doses of 15 mg/kg/day for eight days. All patients also received corticosteroids during the trial. Evaluation of the therapeutic response consisted of the comparison of the number of cysts shown by CT before and three months after treatment, and the evaluation of the clinical status of the patients before and after the trial. Before treatment, the 17 patients had 30 subarachnoid cysticerci, 11 of which were > 50 mm in diameter. Seventeen cysts were located at the convexity of cerebral hemispheres, seven at the sylvian fissure, five at the ambiens cisterns, and one at the cerebellopontine angle cistern. Fourteen patients had seizures, 10 had hemiparesis, three were demented, one had diminution of visual acuity, and one had hemifacial spasm. Brain CT obtained after therapy showed resolution of 27 cysts (90% effectiveness). Fourteen (82%) patients had total resolution of all cysts. All but three patients were asymptomatic. Remaining deficits included hemiparesis in two patients and diminution of visual acuity in one. It is concluded that albendazole is an effective treatment for subarachnoid cysticerci as it causes disappearance of most lesions on CT, and produces considerable improvement in the clinical manifestations of the patients.