Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?
Prior and novel coronaviruses, Coronavirus Disease 2019 (COVID-19), and human reproduction: what is known?
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DOI：
10.1016/j.fertnstert.2020.04.025
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发表时间：
2020-06-01
影响因子：
6.7
通讯作者：
Kawwass, Jennifer F.
中科院分区：
文献类型：
--
作者：
Segars, James;Katler, Quinton;Kawwass, Jennifer F.
目的：总结目前对新型冠状病毒和既往冠状病毒对人类生殖，特别是对男性和女性配子以及妊娠的影响的认识。设计：2020年4月6日PubMed和Embase英文出版物综述。方法：对报道冠状病毒、生殖、病理生理和妊娠的文章进行筛选。干预:没有。主要结局指标：生殖结局、对配子的影响、妊娠结局和新生儿并发症。结果：79份报告构成了审查的基础。冠状病毒与细胞的结合涉及刺突蛋白的S1结构域，包括存在于生殖组织中的受体，包括血管紧张素转换酶-2 （ACE2）、CD26、Ezrin和亲环蛋白。严重急性呼吸综合征冠状病毒1 （SARS-CoV-1）可引起男性严重睾丸炎，导致生殖细胞破坏。报告显示，在2019冠状病毒病（COVID-19）感染后72-90天内，精子浓度和活力下降。在人类卵巢中发现了促性腺激素依赖性ACE2的表达，但尚不清楚sars -冠状病毒2 （CoV-2）是否会对女性配子发生产生不利影响。有证据表明，COVID-19感染的孕产妇病死率低于SARS或中东呼吸综合征（MERS），但坊间报道称，感染后无症状的妇女可能在产后出现呼吸道症状。妊娠期感染2019冠状病毒病与早产有关。产后新生儿母婴传播已有报道。结论：2019冠状病毒病感染可能对部分孕妇及其后代产生不利影响。需要进一步研究来评估SARS-CoV-2感染对男性和女性生育能力的影响。(C) 2020年美国生殖医学学会。)
Objective: To summarize current understanding of the effects of novel and prior coronaviruses on human reproduction, specifically male and female gametes, and in pregnancy.Design: Review of English publications in PubMed and Embase to April 6, 2020.Method(s): Articles were screened for reports including coronavirus, reproduction, pathophysiology, and pregnancy.Intervention(s): None.Main Outcome Measure(s): Reproductive outcomes, effects on gametes, pregnancy outcomes, and neonatal complications.Result(s): Seventy-nine reports formed the basis of the review. Coronavirus binding to cells involves the S1 domain of the spike protein to receptors present in reproductive tissues, including angiotensin-converting enzyme-2 (ACE2), CD26, Ezrin, and cyclophilins. Severe Acute Respiratory Syndrome Coronavirus 1 (SARS-CoV-1) may cause severe orchitis leading to germ cell destruction in males. Reports indicate decreased sperm concentration and motility for 72-90 days following Coronavirus Disease 2019 (COVID-19) infection. Gonadotropin-dependent expression of ACE2 was found in human ovaries, but it is unclear whether SARS-Coronavirus 2 (CoV-2) adversely affects female gametogenesis. Evidence suggests that COVID-19 infection has a lower maternal case fatality rate than SARS or Middle East respiratory syndrome (MERS), but anecdotal reports suggest that infected, asymptomatic women may develop respiratory symptoms postpartum. Coronavirus Disease 2019 infections in pregnancy are associated with preterm delivery. Postpartum neonatal transmission from mother to child has been reported.Conclusion(s): Coronavirus Disease 2019 infection may affect adversely some pregnant women and their offspring. Additional studies are needed to assess effects of SARS-CoV-2 infection on male and female fertility. ((C) 2020 by American Society for Reproductive Medicine.)