Oxytocin and Borderline Personality Disorder.
Oxytocin and Borderline Personality Disorder.
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DOI：
10.1007/7854_2017_26
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发表时间：
2018-01-01
影响因子：
--
通讯作者：
Herpertz, Sabine C
中科院分区：
文献类型：
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作者：
Bertsch, Katja;Herpertz, Sabine C
边缘型人格障碍（BPD）是一种以情感失调、冲动性和人际关系障碍为核心特征的普遍严重的精神障碍。到目前为止，已有6项研究探讨了催产素在BPD发病机制中的作用。虽然发现了催产素对威胁处理和压力反应的有益作用，但其他使用催产素挑战设计的研究却呈现出相当不同的结果。未来的研究必须包括足够大的患者样本，控制性别，并关注已知的与厌恶的早期生活经历相关的机制。
Borderline personality disorder (BPD) is a prevalent and severe mental disorder with affect dysregulation, impulsivity, and interpersonal dysfunction as its core features. Up to now, six studies have been performed to investigate the role of oxytocin in the pathogenesis of BPD. While a beneficial effect of oxytocin on threat processing and stress responsiveness was found, other studies using an oxytocin challenge design presented with rather heterogeneous results. Future studies have to include a sufficiently large sample of patients, control for gender, and focus on mechanisms known to be related to aversive early life experiences.