Isolation of Antagonists of Antigen-Specific Autoimmune T Cell Proliferation
Isolation of Antagonists of Antigen-Specific Autoimmune T Cell Proliferation
复制标题
DOI：
10.1016/j.chembiol.2009.10.011
复制
发表时间：
2009-11-25
影响因子：
--
通讯作者：
Kodadek, Thomas
中科院分区：
文献类型：
--
作者：
Gocke, Anne R.;Udugamasooriya, D. Gomika;Kodadek, Thomas
Antigen-specific T cells play a major role in mediating the pathogenesis of a variety of autoimmune conditions as well as other diseases. In the context of experimental autoimmune encephalomyelitis, a murine model of multiple sclerosis, we present here a general approach to the discovery of highly specific ligands for autoreactive cells. These ligands are obtained from a combinatorial library of hundreds of thousands of synthetic peptoids that is screened simultaneously against two populations of CD4+ T cells. Peptoids that recognize autoreactive T cells with extremely high specificity can be identified in the library. Since no specific knowledge is required regarding the nature of the native antigens recognized by the autoreactive T cells, this technology provides a powerful tool for the enrichment and inhibition of autoimmune cells in a variety of disease states.
