Clinical and histological characterization of transient dermal pain triggered by sweating stimuli
Clinical and histological characterization of transient dermal pain triggered by sweating stimuli
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出汗刺激引发的短暂性皮肤疼痛的临床和组织学特征
DOI：
10.1016/j.alit.2022.01.003
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发表时间：
2022
影响因子：
6.8
通讯作者：
Hide Michihiro
中科院分区：
文献类型：
--
作者：
Takahagi Shunsuke;Okamoto Mayumi;Ishii Kaori;Tanaka Akio;Mizuno Hayato;Harada Naoe;Yanagida Nozomi;Hide Michihiro
背景：出汗引起的皮肤刺痛损害胆碱能性荨麻疹和全身性无汗症患者的生活。然而，皮肤疼痛引起的出汗stimulations.Methods：为了澄清刺痛皮肤疼痛出汗的特点，我们回顾性评估了30例患者的临床和组织病理学表现的主要问题，皮肤疼痛出汗，和治疗的efficiency.Results：皮肤疼痛出汗影响大多数年轻男性。24例患者在出汗和/或少汗时伴有皮疹，6例患者有独立于少汗或皮疹的皮肤疼痛。皮肤疼痛出现后立即暴露于出汗刺激，并消失在大多数30或10分钟。多汗症不一定是普遍的，但本地化或缺席。组织学分析表明，即使没有汗腺的形态学变化和炎症，也会发生皮肤疼痛。仅在26%的患者中发现对汗液内容物过敏。热诱导后患者汗液组胺和血浆组胺含量均显著高于健康人。类固醇脉冲疗法的有效性证明了皮肤疼痛与少汗。药物作用于神经系统和定期出汗诱导活动，促进出汗也是effective.Conclusions：短暂的刺痛皮肤疼痛出现后立即暴露于出汗的刺激，无论发展中的皮疹和/或存在的少汗症，但可能与汗水和血浆组胺。
Background: Tingling dermal pain triggered by sweating impairs the lives of patients with cholinergic urticaria and generalized anhidrosis. However, dermal pain evoked by sweating stimuli has been under investigated.Methods: To clarify characteristics of tingling dermal pain on sweating, we retrospectively evaluated clinical and histopathological manifestations in 30 patients having the main problem of dermal pain on sweating, and the efficacy of treatments.Results: Dermal pain upon sweating affected mostly young males. It accompanied eruptions upon sweating and/or hypohidrosis in 24 patients, while 6 patients had dermal pain independently of hypohidrosis or eruptions. Dermal pain appeared immediately upon exposure to sweating stimuli, and disappeared within mostly 30 or 10 min. Hypohidrosis was not necessarily generalized but localized or absent. Histological analysis revealed that dermal pain could occur even without morphological changes and inflammation of sweat glands. Hypersensitivity to sweat contents was found only in 26% of patients. Sweat histamine and increase of plasma histamine after thermal induction in patients were significantly higher than those in healthy subjects. Effectiveness of steroid pulse therapy was demonstrated for dermal pain with hypohidrosis. Medications acting on nervous systems and regular sweat-inducing activities for promoting perspiration were also effective.Conclusions: Short-lasting tingling dermal pain appears immediately upon exposure to sweating stimuli, regardless of developing eruptions and/or presence of hypohidrosis, but possibly in association with sweat and plasma histamine.