Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines
Mild and efficient copper-catalyzed amination of aryl bromides with primary alkylamines
复制标题
DOI：
10.1021/ol0273396
复制
发表时间：
2003-03-20
期刊：
影响因子：
5.2
通讯作者：
Buchwald, SL
中科院分区：
文献类型：
--
作者：
Kwong, FY;Buchwald, SL
图形开发了一种有效的铜催化芳基溴与伯烷基胺的胺化反应，该胺化使用市售的二乙基水杨酰胺作为配体。该胺化反应可以在90℃下以良好的收率进行。多种官能团与这些反应条件相容。初步结果表明，该反应可以在无溶剂条件下进行，且产率相当。
GraphicsAn efficient copper-catalyzed amination of aryl bromides with primary alkylamines was developed that uses commercially available diethylsalicylamide as the ligand. This amination reaction can be performed at 90 degreesC in good yield. A variety of functional groups are compatible with these reaction conditions. Preliminary results show that this reaction can be carried out under solvent-free conditions with comparable yields.