Parental MHC antigen sharing and pregnancy wastage in captive pigtailed macaques
Parental MHC antigen sharing and pregnancy wastage in captive pigtailed macaques
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DOI：
10.1016/s0165-0378(96)00988-6
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发表时间：
1996-11-01
影响因子：
3.4
通讯作者：
Sackett, GP
中科院分区：
文献类型：
--
作者：
Knapp, LA;Ha, JC;Sackett, GP
在某些人群中，配偶之间的免疫遗传相似性与流产风险增加有关。为探讨非人灵长类动物组织相容性与繁殖性能的关系，将128对短尾猴夫妇根据其先前的繁殖性能分为“繁殖成功”和“不成功”两类。这些夫妇被安排成64个三人组，由个别女性组成，以及一个“成功”和一个“不成功”的配偶。使用微量细胞毒性技术和种特异性同种异体抗血清对个体进行I类MHC抗原分型。配对分析显示，显着更多的“不成功”的夫妇共享MnLA-A抗原比匹配的“成功”的夫妇。条件配对logistic回归分析进一步表明，父母共享MnLA-A抗原是一个更显着的预测妊娠浪费比高龄产妇。在我们的研究人群中，共享MnLA-A抗原预测72%的“不成功”夫妇的妊娠丢失（P < 0.009）。识别影响妊娠成功的组织相容性相关因素可能对人类慢性自然流产、宫内生长迟缓和出生缺陷具有深远的临床意义。在圈养的灵长类动物中，鉴定影响生殖结果的MHC或MHC相关基因可能会导致更有效的群体管理策略，以及开发一种用于理解人类免疫介导的生殖失败的模型。
Among some human populations, immunogenetic similarity between mates is associated with increased risk of pregnancy loss. To investigate the relationship between histocompatibility and reproductive performance in non human primates, 128 pigtailed macaque couples were classified as 'reproductively successful' or 'unsuccessful' according to previous breeding performance. These couples were arranged into 64 triads composed of individual females, and a 'successful' and 'unsuccessful' mate. Individuals were typed for class I MHC antigens using a microcytotoxicity technique and species-specific alloantisera. Matched-pair analysis revealed that significantly more 'unsuccessful' couples shared MnLA-A antigens than did the matched 'successful' couples. Conditional matched-pair logistic regression analysis further revealed that parental sharing of MnLA-A antigens is an even more significant predictor of pregnancy wastage than is advanced maternal age. In our study population, sharing oi MnLA-A antigens predicted 72% of pregnancy loss among 'unsuccessful' couples (P < 0.009). Identification of histocompatibility-associated factors influencing pregnancy success could have profound clinical implications for chronic spontaneous abortion, intra-uterine growth retardation and birth defects in humans. Among captive primates, identification of MHC or MHC-linked genes affecting reproductive outcome could lead to more efficient colony management strategies as well as development of a model for understanding human immunologically-mediated reproductive failure.