Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L cells.
Calcium is permeable through a maitotoxin-activated nonselective cation channel in mouse L cells.
复制标题
钙可通过小鼠 L 细胞中麦芽毒素激活的非选择性阳离子通道渗透。
DOI：
10.1152/ajpcell.1996.270.4.c1145
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Gargus,JJ
中科院分区：
文献类型：
--
作者：
Estacion,M;Nguyen,HB;Gargus,JJ
贝类毒素maitotoxin导致小鼠L细胞成纤维细胞中的非选择性阳离子通道的不可逆开放，与该毒素在其他细胞类型中的作用一致，并且先前证明存在由血小板衍生生长因子激活的28 pS电压不敏感的非选择性阳离子通道。毒素诱导的这些非选择性阳离子通道的开放导致细胞内钙的增加和钙激活钾通道的二次激活。这些影响是完全依赖于细胞外钙离子的流入，支持的结论是，maitotoxin激活的非选择性阳离子通道是渗透钙以及钠和钾。这一发现的含义是，钙信号通过这一渠道的基础，其链接到生长因子的反应。
The shellfish poison maitotoxin causes the irreversible opening of nonselective cation channels in mouse L cell fibroblasts, consistent with the action of this toxin in other cell types and the previously demonstrated existence of 28-pS voltage-insensitive nonselected cation channels that are activated by platelet-derived growth factor in these cells. Toxin-induced opening of these nonselective cation channels led to increases of intracellular calcium and secondary activation of calcium-activated potassium channel. These effects were completely dependent on influx of extracellular calcium, supporting the conclusion that the maitotoxin-activated nonselective cation channels are permeable to calcium as well as to sodium and potassium. The implication of this finding is that calcium signaling through this channel underlies its links into the growth factor response.