Erythrocyte remodeling by malaria parasites
Erythrocyte remodeling by malaria parasites
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DOI：
10.1097/moh.0b013e3280f31b2d
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发表时间：
2007-05-01
影响因子：
3.2
通讯作者：
Mohandas, Narla
中科院分区：
文献类型：
--
作者：
Haldar, Kasturi;Mohandas, Narla
恶性疟原虫（Plasmodium falciparum）是人类疟疾最致命的形式。它是一种感染人类红细胞的原生动物寄生虫，红细胞阶段是该病所有症状和病理的原因。感染的关键是在进入时形成寄生空泡膜，细胞内寄生虫在其中增殖。由于红细胞缺乏内吞机制，令人惊讶的是它们可以被病原体感染。本文综述了红细胞-疟疾相互作用的最新研究，这些研究提供了对红细胞膜特性以及寄生虫重塑红细胞的机制的见解。最近的研究表明，寄生虫和红细胞成分都通过广泛的重塑宿主膜来调节寄生虫的进入和细胞内生长，这些重塑事件包括寄生虫进入宿主细胞膜时的内陷，导致细胞内生物周围液泡的产生和维持，以及抗原的发展。结论：由于许多相关的毒力事件与严重的疾病病理有关，因此疟疾红细胞重塑事件的发生对人类宿主来说代价很大。
Purpose of review Plasmodium falciparum causes the most virulent form of human malarias. It is a protozoan parasite that infects human erythrocytes and the erythrocytic stages are responsible for all symptoms and pathologies of the disease. Critical to infection is the formation of a parasitophorous vacuolar membrane at the time of entry and within which the intracellular parasite proliferates. Since erythrocytes lack endocytic machinery, it is surprising that they can be infected by pathogens. This review summarizes recent studies of the erythrocyte-malaria interaction that have provided insights into properties of erythrocyte membranes as well as parasite mechanisms that remodel the erythrocyte.Recent findings Themes revealed by recent literature suggest that both parasite and erythrocyte components regulate parasite entry and intracellular growth by extensively remodeling host membranes, These remodeling events include the invagination of the host cell membrane during parasite entry that results in the creation and maintenance of a vacuole that surrounds the intracellular organism, and the development of antigenic, structural and transport alterations during intracellular parasite developmentSummary The implications are that malarial erythrocyte remodeling events occur at a significant cost to the human host since many of the associated virulence events have been linked to severe disease pathologies.