Seven-Membered Cyclic Acetals
Seven-Membered Cyclic Acetals
复制标题
七元环缩醛
DOI：
10.1021/jo01357a019
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发表时间：
1957
影响因子：
3.6
通讯作者：
Dexter B. Pattison
中科院分区：
文献类型：
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作者：
Dexter B. Pattison
本文介绍了由醛和二元醇衍生的羟基间含四个碳原子的七元环状缩醛的制备和性质。有两个竞争反应可能发生，要么闭环所需的七元缩醛或脱水的乙二醇四氢呋喃衍生物。这在下面用于合成4，4，7，7-四甲基-1，3-二氧杂环庚烷的反应式中说明。
This paper describes the preparation and properties of various seven-membered cyclic acetals derived from aldehydes and dihydric alcohols con-taining fourcarbon atoms between hydroxyl groups. There are two competing reactionswhich can occur, either ring closure to the desired seven-membered acetal or dehydration of the glycol to a tetrahydrofuran derivative. This is illustrated below in the equation for the synthesis of 4, 4, 7, 7-tetramethyl-1, 3-dioxepane.