"...those left behind." Biology and oncology of invasive glioma cells
"...those left behind." Biology and oncology of invasive glioma cells
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DOI：
10.1038/sj.neo.7900034
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发表时间：
1999-08-01
期刊：
影响因子：
--
通讯作者：
Giese, Alf
中科院分区：
文献类型：
--
作者：
Berens, Michael E.;Giese, Alf
尽管近年来在脑肿瘤的手术和放射治疗方面取得了重大的技术进步，但它们对患者临床结果的影响一直令人失望。胶质瘤患者面临的管理挑战的一个基本来源是恶性细胞潜伏着侵入邻近正常大脑的倾向。侵袭性肿瘤细胞逃脱了手术切除，并在地理上避开了致命的辐射暴露。最近对胶质瘤细胞侵袭的生物化学和分子决定因素的深入了解为揭示该疾病的潜在生物学特征以及阐明可能的新的治疗靶点提供了有价值的见解。对迁移和侵袭的高度承诺伴随着胶质瘤细胞增殖活性的降低。与侵袭和迁移相一致的微环境操作也可能影响胶质瘤细胞对细胞毒治疗的反应。胶质瘤细胞侵袭表型的这些侧枝方面应该被进一步探索和开发为新的抗胶质瘤治疗方法。
Although significant technical advances in surgical and radiation treatment for brain tumors have emerged in recent years, their impact on clinical outcome for patients has been disappointing. A fundamental source of the management challenge presented by glioma patients is the insidious propensity of the malignant cells to invade into adjacent normal brain. Invasive tumor cells escape surgical removal and geographically dodge lethal radiation exposure. Recent improved understanding of the biochemistry and molecular determinants of glioma cell invasion provide valuable insight to the underlying biological features of the disease, as well as illuminating possible new therapeutic targets. Heightened commitment to migrate and invade is accompanied by a glioma cell's reduced proliferative activity. The microenvironmental manipulations coincident to invasion and migration may also impact the glioma cell's response to cytotoxic treatments. These collateral aspects of the glioma cell invasive phenotype should be further explored and exploited as novel antiglioma therapies.