HAEMORRHAGIC SHOCK AND ENCEPHALOPATHY: A NEW SYNDROME WITH A HIGH MORTALITY IN YOUNG CHILDREN
HAEMORRHAGIC SHOCK AND ENCEPHALOPATHY: A NEW SYNDROME WITH A HIGH MORTALITY IN YOUNG CHILDREN
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失血性休克和脑病：一种在幼儿中死亡率很高的新综合征
DOI：
10.1016/s0140-6736(83)90057-0
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
D. Matthew
中科院分区：
文献类型：
--
作者：
M. Levin;JonathanD. S. Kay;J. Gould;M. Hjelm;J. Pincott;R. Dinwiddie;D. Matthew
去年，有十名婴儿因新的或以前未被识别的疾病入院，其特征是急性发作的脑病、发烧、休克、水样腹泻、严重的弥散性血管内凝血以及肾和肝功能障碍。其中七名婴儿死亡。尚未确定具体的病原体，但初步研究表明，该疾病的病理生理学可能涉及蛋白水解酶（如胰蛋白酶）释放到循环中，从而破坏微循环。
In the past year, ten infants have been admitted to hospital with a new or previously unrecognised disorder, characterised by an acute onset of encephalopathy, fever, shock, watery diarrhoea, severe disseminated intravascular coagulation, and renal and hepatic dysfunction. Seven of the infants died. No specific causative agent has been identified, but preliminary studies suggest that the pathophysiology of the disease may involve release of proteolytic enzymes (such as trypsin) into the circulation, with destruction of the microcirculation.