Aquaporins and glycerol metabolism
Aquaporins and glycerol metabolism
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DOI：
10.1016/j.bbamem.2006.01.008
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发表时间：
2006-08-01
影响因子：
3.4
通讯作者：
Funahashi, Tohru
中科院分区：
文献类型：
--
作者：
Hibuse, Toshiyuki;Maeda, Norikazu;Funahashi, Tohru
水通道蛋白（AQP）的发现对生命科学产生了重大影响。水通道蛋白（AQP）是一类广泛存在于植物、单细胞生物、无脊椎动物和脊椎动物体内的同源水通道。到目前为止，已经在人体中发现了13种AQP。AQP3、7、9和10被亚分类为水甘油孔蛋白，其使甘油以及水透化。许多研究者已经证明，水通道蛋白在维持水平衡中起着至关重要的作用，但一些水通道蛋白作为甘油通道的生理意义还没有完全理解。脂肪组织是甘油的主要来源，甘油是脂肪组织发生的底物之一。本文综述了近年来甘油通过水甘油通道蛋白代谢的研究进展，并简要讨论了甘油通道在脂肪组织和肝脏中的重要性。(c)2006 Elsevier B.V.保留所有权利。
The discovery of aquaporin (AQP) has made a great impact on life sciences. AQPs are a family of homologous water channels widely distributed in plants, unicellular organisms, invertebrates, and vertebrates. So far, 13 AQPs have been identified in human. AQP3, 7, 9, and 10 are subcategorized as aquaglyceroporins which permeabilize glycerol as well as water. Many investigators have demonstrated that AQPs play a crucial role in maintaining water homeostasis, but the physiological significance of some AQPs as a glycerol channel is not fully understood. Adipose tissue is a major source of glycerol and glycerol is one of substrates for gluconeogenesis. This review focuses on recent studies of glycerol metabolism through aquaglyceroporins, and briefly discusses the importance of glycerol channel in adipose tissues and liver. (c) 2006 Elsevier B.V. All rights reserved.