Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.
Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years.
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DOI：
10.3390/molecules22020191
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发表时间：
2017-01-24
期刊：
影响因子：
--
通讯作者：
Loguercio C
中科院分区：
文献类型：
--
作者：
Federico A;Dallio M;Loguercio C
水飞蓟素是水飞蓟或水飞蓟的提取物，其主要活性化合物是水飞蓟宾，具有显着的生物作用。由于其抗氧化、抗炎和抗纤维化能力，它可用于治疗不同的肝脏疾病，特别是慢性肝病、肝硬化和肝细胞癌。事实上，水飞蓟素的抗氧化和抗炎作用旨在通过炎症级联软化和免疫系统调节来减少病毒相关的肝损伤。它还具有与丙型肝炎病毒感染中静脉注射相关的直接抗病毒作用。对于酒精滥用，水飞蓟素能够增加细胞活力并减少脂质过氧化和细胞坏死。此外，水飞蓟素/水飞蓟宾的使用对非酒精性脂肪肝具有重要的生物学作用。这些物质通过干预各种治疗目标来拮抗非酒精性脂肪肝的进展：氧化应激、胰岛素抵抗、肝脏脂肪堆积和线粒体功能障碍。水飞蓟素还通过调节不同的分子模式用于治疗肝硬化和肝细胞癌，这两种疾病代表不同肝病的共同终末期。因此，本综述的目的是审查有关水飞蓟素/水飞蓟宾对慢性肝病、肝硬化和肝细胞癌的影响的科学研究。
Silymarin is the extract of Silybum marianum, or milk thistle, and its major active compound is silybin, which has a remarkable biological effect. It is used in different liver disorders, particularly chronic liver diseases, cirrhosis and hepatocellular carcinoma, because of its antioxidant, anti-inflammatory and antifibrotic power. Indeed, the anti-oxidant and anti-inflammatory effect of silymarin is oriented towards the reduction of virus-related liver damages through inflammatory cascade softening and immune system modulation. It also has a direct antiviral effect associated with its intravenous administration in hepatitis C virus infection. With respect to alcohol abuse, silymarin is able to increase cellular vitality and to reduce both lipid peroxidation and cellular necrosis. Furthermore, silymarin/silybin use has important biological effects in non-alcoholic fatty liver disease. These substances antagonize the progression of non-alcoholic fatty liver disease, by intervening in various therapeutic targets: oxidative stress, insulin resistance, liver fat accumulation and mitochondrial dysfunction. Silymarin is also used in liver cirrhosis and hepatocellular carcinoma that represent common end stages of different hepatopathies by modulating different molecular patterns. Therefore, the aim of this review is to examine scientific studies concerning the effects derived from silymarin/silybin use in chronic liver diseases, cirrhosis and hepatocellular carcinoma.
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