PREFERENTIAL ACCUMULATION OF MATURE NK-CELLS DURING HUMAN IMMUNOSENESCENCE
PREFERENTIAL ACCUMULATION OF MATURE NK-CELLS DURING HUMAN IMMUNOSENESCENCE
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DOI：
10.1002/jcb.240500407
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发表时间：
1992-12-01
影响因子：
4
通讯作者：
SVANBORG, A
中科院分区：
文献类型：
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作者：
KRISHNARAJ, R;SVANBORG, A
自然杀伤细胞的主要组织相容性复合物——不受限制的、细胞介导的、组成性的抗肿瘤细胞毒功能在健康老年人中得到高度保存。对免疫衰老过程中自然杀伤细胞相关表型表达的动态研究表明，在衰老过程中，某些自然杀伤细胞亚群数量和比例发生了选择性、双向和不成比例的变化。随着年龄的增长，平均自然杀伤细胞亚群比率（%CD16+CD57+超过%CD56+CD57-）从年轻成人的0.7逐渐增加到4.6，这主要是由于%CD16+57+细胞增加了三倍，而%CD56+57-表型则适度减少（-54%）。自然杀伤表型比率和细胞毒性活性的平行增加可能代表了这些细胞成熟状态的转变。在此基础上，提出了一种自然杀伤细胞免疫衰老模型。因此，并非所有的免疫衰老变化都是有害的；有些甚至可以提高生存的潜力，代表一种适应性免疫衰老的变化。
The major histocompatibility complex-unrestricted, cell-mediated, constitutive anti-tumor cytotoxic function of natural killer cells is highly preserved in healthy elderly. A study of the dynamics of expression of natural killer cell-associated phenotypes during immunosenescence shows that selective, bidirectional, and disproportionate changes in certain natural killer cell subset number and ratio take place during aging. The mean natural killer cell subset ratio (%CD16+CD57+ over %CD56+CD57-) gradually increases from a young adult level of 0.7 to 4.6 with advancing age predominantly due to a tripling of %CD16+57+ cells as opposed to a moderate decrease (-54%) in %CD56+57- phenotype. The parallel increase in natural killer phenotype ratio and cytotoxic activity might represent a shift in the maturity status of these cells. Based on these findings, a model of natural killer cell immunosenescence is proposed. It is concluded that not all immunosenescent changes need be detrimental; some may even improve the potential for survival and represent an adaptational immunosenescent change.