Limited sequence variation in human T-lymphotropic virus type 1 isolates from North American and African patients.
Limited sequence variation in human T-lymphotropic virus type 1 isolates from North American and African patients.
复制标题
来自北美和非洲患者的人类 T 淋巴细胞病毒 1 型分离株的序列变异有限。
DOI：
10.1016/0042-6822(91)90654-t
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发表时间：
1991
期刊：
影响因子：
3.7
通讯作者：
Ratner,L
中科院分区：
文献类型：
--
作者：
Paine,E;Garcia,J;Philpott,TC;Shaw,G;Ratner,L
从来自两名北美患者和一名非洲成人T细胞白血病/淋巴瘤患者的三个HTLV-I克隆的env基因中确定核苷酸序列（从其中一个分离株中确定了env和3′LTR之间的ATLL区域）。将这些数据与来自两名日本ATLL患者的HTLV-I分离株的序列进行比较，一名日本HTLV-I相关脊髓病或热带痉挛性下肢轻瘫（HAM/TSP）患者和一名加勒比ATLL患者。发现编码区和非编码区的核苷酸序列变异<6%。预测的氨基酸序列在包膜中的变化范围为0.6 - 1.8%，在雷克斯中为0-3.7%，在tax基因产物中为0.8-2.5%，在pX-I开放阅读框架中为3-14.0%。表面包膜蛋白（SU-gp 46）的预测的氨基酸序列的比较表明，不同地理来源的菌株之间的差异大于从世界同一地区获得的菌株之间的差异。
Nucleotide sequences were determined from theenvgenes of three HTLV-I clones derived from two North American patients and one African patient with adult T-cell leukemia/lymphoma (ATLL region, betweenenvand the 3′LTR, were determined from one of these isolates. These data were compared to sequences derived from HTLV-I isolates of two Japanese ATLL patients, a Japanese patient with HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP) and a Caribbean ATLL patient. Nucleotide sequence variation was found to be <6% in coding and noncoding regions. Predicted amino acid sequences varied between 0.6 and 1.8% in the envelope, 0–3.7% in rex, 0.8–2.5% in the tax gene product, and 3–14.0% in the pX-I open reading frame. Comparisons of the predicted amino acid sequences of the surface envelope protein (SU-gp46) suggest that the variation between isolates of different geographical origins is greater than that between isolates obtained from the same region of the world.