Clinicopathological evaluation of Sox10 expression in diffuse-type gastric adenocarcinoma
Clinicopathological evaluation of Sox10 expression in diffuse-type gastric adenocarcinoma
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DOI：
10.1007/s12032-016-0865-2
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发表时间：
2017-01-01
期刊：
影响因子：
3.4
通讯作者：
Tanaka, Shinya
中科院分区：
文献类型：
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作者：
Kato, Marin;Nishihara, Hiroshi;Tanaka, Shinya
Sox 10是一种转录因子，在正常组织的多种发育过程中调节Wnt/β-catenin信号通路。Sox 10还在可变实体肿瘤中表达，例如乳腺癌、唾液腺肿瘤、肝细胞癌、卵巢肿瘤、鼻咽癌、前列腺癌和消化道癌。Sox 10在肿瘤发生中的作用仍有争议，特别是在消化道肿瘤中，因此，我们进行了41例弥漫型胃腺癌（DGA）的Sox 10表达的临床病理评价。我们通过免疫组化染色和实时定量逆转录聚合酶链反应检测了Sox 10的表达，并评估了Sox 10表达与临床病理因素之间的相关性。Sox 10的低水平表达与免疫组化评估的高水平静脉浸润显著相关，而实时PCR分析时，它与高水平淋巴管渗透显著相关。对41例患者的生存分析表明，高水平的血管渗透是一个统计学上不良的预后因素，表明Sox 10的减损将通过加速血管浸润而导致不利的患者预后。在这项研究中，我们揭示了评估Sox 10表达的临床益处，以预测DGA患者预后不良的血管渗透风险。
Sox10, one of the transcription factors, regulates Wnt/beta-catenin signaling in diverse developmental processes in normal tissues. Sox10 is also expressed in variable solid tumors such as breast cancer, salivary tumor, hepatocellular carcinoma, ovarian tumor, nasopharyngeal carcinoma, prostate cancer, and digestive cancer. The role of Sox10 during tumorigenesis is still controversial, especially in digestive cancers; thus, we performed clinicopathological evaluation of Sox10 expression in 41 cases of diffuse-type gastric adenocarcinoma (DGA). We examined the expression of Sox10 by immunohistochemical staining and real-time quantitative reverse transcriptase PCR and evaluated the correlation between Sox10 expression and clinicopathological factors. A low-level expression of Sox10 was significantly associated with high-level venous invasion by immunohistochemical evaluation, while it was significantly associated with high-level lymphatic permeation when analyzed by real-time PCR assay. Survival analysis of 41 cases indicated that high level of vascular permeation was a statistically poor prognostic factor, suggesting that derogation of Sox10 would lead to unfavorable patients' outcome through the acceleration of vascular invasion. In this study, we revealed the clinical benefit of evaluation of Sox10 expression to predict the risk of vascular permeation which yields patients' poor prognosis in DGA.