Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2
Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2
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DOI：
10.1093/infdis/jiaa471
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发表时间：
2020-10-15
影响因子：
6.4
通讯作者：
Steinmann, Eike
中科院分区：
文献类型：
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作者：
Meister, Toni Luise;Bruggemann, Yannick;Steinmann, Eike
持续不断的严重急性呼吸综合征冠状病毒2(SARS-CoV-2)大流行对全球健康构成重大威胁。最近的研究表明，在2019年早期冠状病毒病期间，咽喉和唾液腺是病毒复制和传播的主要部位，因此倡导使用口服防腐剂。然而，针对SARS-CoV-2的口腔含漱液的抗病毒效果尚未得到检验。在这里，我们评估了在模拟鼻咽分泌物的条件下，不同可用的口腔漱口水对SARS-CoV-2的杀灭病毒活性。几种在体外具有显著的SARS-CoV-2灭活特性的制剂支持这样的观点，即口腔漱口可以减少唾液中的病毒载量，从而可以降低SARS-CoV-2的传播。
The ongoing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic creates a significant threat to global health. Recent studies suggested the significance of throat and salivary glands as major sites of virus replication and transmission during early coronavirus disease 2019, thus advocating application of oral antiseptics. However, the antiviral efficacy of oral rinsing solutions against SARS-CoV-2 has not been examined. Here, we evaluated the virucidal activity of different available oral rinses against SARS-CoV-2 under conditions mimicking nasopharyngeal secretions. Several formulations with significant SARS-CoV-2 inactivating properties in vitro support the idea that oral rinsing might reduce the viral load of saliva and could thus lower the transmission of SARS-CoV-2.