An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons.
An inhibitory effect of vitamin A on the induction of tumors of forestomach and cervix in the Syrian hamster by carcinogenic polycyclic hydrocarbons.
复制标题
维生素A对致癌多环烃诱发叙利亚仓鼠前胃和子宫颈肿瘤的抑制作用。
作者：
E. Chu;R. A. Malmgren
对叙利亚仓鼠口服7,12 -二甲基苯并蒽（DMBA）或苯并(a)芘（Bp）可诱导前胃和小肠的角化不良病变和癌，但只有DMBA可诱导食管角化不良病变。绘制叙利亚仓鼠的子宫颈，会阴皮肤诱发DMBA， 100%的动物阴道癌，22%的动物宫颈癌。在同样用DMBA或Bp治疗的动物中，在饮食中添加0.5%的维生素Apalmitate可以防止胃肠道癌的发展；将维生素a -棕榈酸酯添加到用于子宫颈涂漆的液体中，可以预防子宫颈和阴道癌的发展，但不能抑制会阴皮肤癌的发展。本文考虑了维生素A对仓鼠粘膜鳞状细胞癌诱导的抑制作用。
SUMMARY The oral administration of 7 , 12-dimethylbenzanthracene (DMBA) or benzo(a) pyrene(Bp) to Syrian hamsters induced dyskeratotic lesions and carcinoma of the forestomach and small intestine but only the DMBA induced dyskeratotic lesions of the esophagus. Painting the uterine cervix of Syrian hamsters with DMBA in duced perineal skin and vaginal carcinoma in 100% of the animals and cervical car cinoma in 22 % of the animals. In animals similarly treated with DMBA or Bp the addition of 0.5 % vitamin Apalmitate to the diet prevented the development of carcinoma of the gastrointestinal tract ; adding the vitamin A-palmitate to the fluid used for painting the cervix pre vented the development of carcinoma of cervix and vagina but did not inhibit the development of carcinoma of the perineal skin. The implication of the inhibitory effect of Vitamin A on the induction of squamous cell carcinoma of the mucous meni branes in the hamster is considered.