Preparation and characterization of carvedilol-loaded poly(d,l) lactide nanoparticles/microparticles as a sustained-release system
Preparation and characterization of carvedilol-loaded poly(d,l) lactide nanoparticles/microparticles as a sustained-release system
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DOI：
10.1080/00914037.2016.1263951
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发表时间：
2017-01-01
影响因子：
3.2
通讯作者：
Sawalha, Hassan
中科院分区：
文献类型：
--
作者：
Assali, Mohyeddin;Zaid, Abdel Naser;Sawalha, Hassan
制备卡维地洛聚（d，l）-丙交酯纳米粒/微粒。通过原子力显微镜分析研究有机溶剂和聚合物量的影响，优化了开发的颗粒的尺寸和形态，以研究卡维地洛的释放曲线。在丙酮的情况下，获得了最小尺寸为125 nm的球形颗粒，在二氯甲烷的情况下，获得了最大尺寸为970 nm的球形颗粒，从而形成微粒。通过差示扫描量热仪和傅里叶变换红外光谱证实了这种相互作用。多室系统（纯卡维地洛，负载的纳米颗粒和微粒）的体外释放曲线已显示与T滞后模型的Korsmeyer-Peppas的持续释放。
Carvedilol poly(d,l)-lactide nanoparticles/microparticles were prepared. The size and morphology of the developed particles were optimized to study the carvedilol release profile by studying the effect of organic solvents and polymer amount through atomic force microscopy analysis. Spherical particles were obtained with a minimum size of 125nm in the case of acetone and a maximum size of 970nm in the case of dichloromethane affording microparticles formation. The interaction was confirmed by differential scanning calorimeter and Fourier transform infrared. The in vitro release profile of the multicompartment system (pure carvedilol, loaded nanoparticles and microparticles) has shown a sustained release with Korsmeyer-Peppas with T lag model.