Aberrant regulation of Wnt signaling in hepatocellular carcinoma.
Aberrant regulation of Wnt signaling in hepatocellular carcinoma.
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肝细胞癌中 Wnt 信号传导的异常调节
DOI：
10.3748/wjg.v22.i33.7486
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发表时间：
2016-09-07
影响因子：
4.3
通讯作者：
Zhu F
中科院分区：
文献类型：
--
作者：
Liu LJ;Xie SX;Chen YT;Xue JL;Zhang CJ;Zhu F
肝细胞癌（HCC）是世界上最致命的恶性肿瘤之一。多种信号通路，包括 wingless/int-1 (Wnt) 信号通路，已被证明在 HCC 中普遍被激活。 Wnt 信号通路可通过连环蛋白 β1 (CTNNB1) 依赖性（也称为“规范”）和 CTNNB1 独立性（通常称为“非规范”）途径触发。具体来说，经典 Wnt 通路是 HCC 中最常报道的通路之一。三种复合物（细胞表面受体复合物、细胞质破坏复合物和核 CTNNB1/T 细胞特异性转录因子/淋巴增强子结合因子转录复合物）的异常调节都与 HCC 有关。尽管非经典Wnt通路鲜有报道，但Wnt/平面细胞极性通路和Wnt/Ca2+通路这两条主要的非经典通路参与肝癌发生的调控。有趣的是，在 HCC 中，经典 Wnt 通路被非经典 Wnt 信号传导所拮抗。此外，其他信号级联也被证明可以通过 HCC 发病机制中的串扰来调节 Wnt 通路。这篇综述为新出现的证据提供了一个视角，即 Wnt 信号传导的异常调节是 HCC 发展的关键机制。此外，不同信号通路之间的串扰可能有利于肝癌新分子靶点的开发。
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies in the world. Several signaling pathways, including the wingless/int-1 (Wnt) signaling pathway, have been shown to be commonly activated in HCC. The Wnt signaling pathway can be triggered via both catenin β1 (CTNNB1)-dependent (also known as “canonical”) and CTNNB1-independent (often referred to as “non-canonical”) pathways. Specifically, the canonical Wnt pathway is one of those most frequently reported in HCC. Aberrant regulation from three complexes (the cell-surface receptor complex, the cytoplasmic destruction complex and the nuclear CTNNB1/T-cell-specific transcription factor/lymphoid enhancer binding factor transcriptional complex) are all involved in HCC. Although the non-canonical Wnt pathway is rarely reported, two main non-canonical pathways, Wnt/planar cell polarity pathway and Wnt/Ca2+ pathway, participate in the regulation of hepatocarcinogenesis. Interestingly, the canonical Wnt pathway is antagonized by non-canonical Wnt signaling in HCC. Moreover, other signaling cascades have also been demonstrated to regulate the Wnt pathway through crosstalk in HCC pathogenesis. This review provides a perspective on the emerging evidence that the aberrant regulation of Wnt signaling is a critical mechanism for the development of HCC. Furthermore, crosstalk between different signaling pathways might be conducive to the development of novel molecular targets of HCC.
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影响因子：
56.9
作者：
Behrens, J;Jerchow, BA;Birchmeier, W
通讯作者：
Birchmeier, W
影响因子：
10.5
作者：
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4.3
作者：
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通讯作者：
Xiong, Qi-Ru
影响因子：
8
作者：
Desbois-Mouthon, C;Cadoret, A;Capeau, J
通讯作者：
Capeau, J