Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats
Antidepressant-like effects of omega-3 fatty acids in postpartum model of depression in rats
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DOI：
10.1016/j.bbr.2014.05.036
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发表时间：
2014-09-01
影响因子：
2.7
通讯作者：
Muhammad, Sani Ismaila
中科院分区：
文献类型：
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作者：
Arbabi, Leila;Baharuldin, Mohamad. Taufik Hidayat;Muhammad, Sani Ismaila
产后抑郁症（PPD）是一种精神疾病，发生在10-15%的育龄妇女。据推测，鱼油中的ω-3脂肪酸可能会减轻抑郁症状。为了验证这一假说，本研究建立了产后抑郁症动物模型。切除卵巢的雌性大鼠接受模拟妊娠（HSP）方案，并接受孕酮和苯甲酸雌二醇或载体23天，模拟实际大鼠的妊娠。激素终止后的天数被视为产后期。在产后第1天，在5个产后诱导组和1个溶媒组中开始强制喂食鲱鱼油（作为omega-3的来源），每只大鼠给予1、3和9 g/kg/d三种剂量，氟西汀15 mg/kg/d和蒸馏水2 ml/d，并持续15天。在产后第15天，对所有组进行强迫游泳试验（FST）和旷场试验（OFF），然后进行生化测定。结果表明，产后诱导的大鼠未处理的鲱鱼鱼油，表现出增加不动时间，在FST，海马皮质酮浓度和血浆皮质酮水平，促炎细胞因子。这些抑郁症相关的影响减弱了补充鲱鱼鱼油的剂量为3和9克/公斤。此外，补充鲱鱼鱼油的大鼠的结果与临床有效的抗抑郁药氟西汀治疗的大鼠相当。综上所述，这些结果表明，富含omega-3的鲱鱼鱼油对产后抑郁症产生有益影响，并降低与抑郁症相关的生物标志物，如皮质酮和促炎细胞因子。(C)2014作者由爱思唯尔公司出版
Postpartum depression (PPD) is a psychiatric disorder that occurs in 10-15% of childbearing women. It is hypothesized that omega-3 fatty acids, which are components of fish oil, may attenuate depression symptoms. In order to examine this hypothesis, the animal model of postpartum depression was established in the present study. Ovariectomized female rats underwent hormone-simulated pregnancy (HSP) regimen and received progesterone and estradiol benzoate or vehicle for 23 days, mimicking the actual rat's pregnancy. The days after hormone termination were considered as the postpartum period. Forced feeding of menhaden fish oil, as a source of omega-3, with three doses of 1, 3, and 9 g/kg/d, fluoxetine 15 mg/kg/d, and distilled water 2 ml/d per rat started in five postpartum-induced and one vehicle group on postpartum day 1 and continued for 15 consecutive days. On postpartum day 15, all groups were tested in the forced swimming test (FST) and open field test (OFF), followed by a biochemical assay. Results showed that the postpartum-induced rats not treated with menhaden fish oil, exhibited an increase in immobility time seen in FST, hippocampal concentration of corticosterone and plasmatic level of corticosterone, and pro-inflammatory cytokines. These depression-related effects were attenuated by supplementation of menhaden fish oil with doses of 3 and 9 g/kg. Moreover, results of rats supplemented with menhaden fish oil were comparable to rats treated with the clinically effective antidepressant, fluoxetine. Taken together, these results suggest that menhaden fish oil, rich in omega-3, exerts beneficial effect on postpartum depression and decreases the biomarkers related to depression such as corticosterone and pro-inflammatory cytokines. (C) 2014 The Authors. Published by Elsevier B.V.