PML diagnostic criteria
PML diagnostic criteria
复制标题
PML诊断标准
作者：
J. Berger;A. Aksamit;D. Clifford;L. Davis;I. Koralnik;J. Sejvar;R. Bartt;E. Major;A. Nath
Objective: To establish criteria for the diagnosis of progressive multifocal leukoencephalopathy (PML). Methods: We reviewed available literature to identify various diagnostic criteria employed. Several search strategies employing the terms “progressive multifocal leukoencephalopathy” with or without “JC virus” were performed with PubMed, SCOPUS, and EMBASE search engines. The articles were reviewed by a committee of individuals with expertise in the disorder in order to determine the most useful applicable criteria. Results: A consensus statement was developed employing clinical, imaging, pathologic, and virologic evidence in support of the diagnosis of PML. Two separate pathways, histopathologic and clinical, for PML diagnosis are proposed. Diagnostic classification includes certain, probable, possible, and not PML. Conclusion: Definitive diagnosis of PML requires neuropathologic demonstration of the typical histopathologic triad (demyelination, bizarre astrocytes, and enlarged oligodendroglial nuclei) coupled with the techniques to show the presence of JC virus. The presence of clinical and imaging manifestations consistent with the diagnosis and not better explained by other disorders coupled with the demonstration of JC virus by PCR in CSF is also considered diagnostic. Algorithms for establishing the diagnosis have been recommended.
影响因子：
3.2
作者：
W. Choe;A. Albright;J. Sulcove;S. Jaffer;J. Hesselgesser;E. Lavi;P. Crino;D. Kolson
通讯作者：
W. Choe;A. Albright;J. Sulcove;S. Jaffer;J. Hesselgesser;E. Lavi;P. Crino;D. Kolson
磁共振脑成像对艾滋病相关巨细胞病毒脑炎缺乏敏感性。
DOI：
10.3109/13550289609146905
发表时间：
1996
期刊：
Journal of neurovirology.
影响因子：
--
作者：
Clifford,DB;Arribas,JR;Storch,GA;Tourtellote,W;Wippold,FJ
通讯作者：
Wippold,FJ
利用免疫组织化学和聚合酶链反应通过立体定向脑活检诊断进行性多灶性白质脑病。
影响因子：
1.8
作者：
Silver,SA;Arthur,RR;Erozan,YS;Sherman,ME;McArthur,JC;Uematsu,S
通讯作者：
Uematsu,S