INHIBITION OF ACTIVIN RECEPTOR SIGNALING PROMOTES NEURALIZATION IN XENOPUS
INHIBITION OF ACTIVIN RECEPTOR SIGNALING PROMOTES NEURALIZATION IN XENOPUS
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DOI：
10.1016/0092-8674(94)90319-0
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发表时间：
1994-04-22
期刊：
影响因子：
64.5
通讯作者：
MELTON, DA
中科院分区：
文献类型：
--
作者：
HEMMATIBRIVANLOU, A;MELTON, DA
截短的激活素II型受体的表达，阻断了激活素的信号传递，使原本可能成为表皮细胞的胚胎细胞的外植体神经化。这种神经化是直接的，不需要中胚层的存在。诱导的神经组织表达中枢神经系统的一般分子标记以及沿前后轴的一系列神经标记。在整个胚胎的背景下，这种被截断的激活素受体的表达将预期的外胚层和内胚层转向神经命运。我们认为，抑制激活素II型受体信号导致非洲爪哇胚胎的细胞采用神经命运。这些结果以及之前在果蝇身上进行的实验表明，脊椎动物和无脊椎动物神经系统的形成是通过共同的策略进行的。
Expression of a truncated activin type II receptor, which blocks signaling by activin, neuralizes explants of embryonic cells that would otherwise become epidermal cells. This neuralization is direct and does not require the presence of mesoderm. The induced neural tissue expresses general molecular markers of the central nervous system as well as an array of neural markers along the anteroposterior axis. In the context of the whole embryo, expression of this truncated activin receptor diverts prospective ectoderm and endoderm to a neural fate. We propose that inhibition of the activin type II receptor signaling causes the cells of Xenopus embryos to adopt a neural fate. These results, along with previous experiments performed in Drosophila, suggest that the formation of the nervous system in vertebrates and invertebrates occurs by a common strategy.