Lever arm model of force generation by actin-myosin-ATP
Lever arm model of force generation by actin-myosin-ATP
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DOI：
10.1021/bi9907633
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发表时间：
1999-08-03
期刊：
影响因子：
2.9
通讯作者：
Highsmith, S
中科院分区：
文献类型：
--
作者：
Highsmith, S
我的目标是为读者提供一个狭隘的视角，对目前的工作假设，杠杆臂模型，从化学能的肌肉运动蛋白质的力生产机制。最近的数据大规模域重排和它们的基本原子水平的结构变化，并严格评估。重点是什么额外的信息是需要制定和测试杠杆臂模型作为一个分子机制。为了简化假说的陈述，我试图严格限制参考文献的数量，并尽可能使用最现代的参考文献。在许多情况下，我不会引用重要观察或思想的最早出版物。我希望我的同事们能原谅我。为了获得该领域发现的更完整的历史图景，人们可以从这里引用的最近文章中回溯，或者查阅一篇综述（1）。
My goal is to provide the reader with a narrowly focused perspective on the current working hypothesis, the lever arm model, for the mechanism of force production from chemical energy by muscle motor proteins. Recent data on large-scale domain rearrangements and their underlying atomic level structural changes are presented and critically evaluated. The emphasis is on what additional information is needed to formulate and test the lever arm model as a molecular mechanism. To simplify the presentation of the hypothesis, I have tried to limit severely the number of references, and to use the most contemporary ones when possible. In many cases, I do not cite the earliest publications of important observations or ideas. I hope that my colleagues will be forgiving. To obtain a more integrated historical picture of discoveries in the field, one can work backward from the recent articles cited here or consult a review (1).