Longitudinal assessment of negative symptoms in schizophrenia/schizoaffective patients, other psychotic patients, and depressed patients
Longitudinal assessment of negative symptoms in schizophrenia/schizoaffective patients, other psychotic patients, and depressed patients
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DOI：
10.1093/oxfordjournals.schbul.a006893
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发表时间：
2001-01-01
影响因子：
6.6
通讯作者：
Harrow, M
中科院分区：
文献类型：
--
作者：
Herbener, ES;Harrow, M
本研究评估了10年随访期内精神分裂症/情感障碍、其他精神病和抑郁症患者之间阴性症状表现的差异。对150名精神分裂症或情感性精神障碍（SZ/SZAF）、其他精神病性精神障碍（OP）和抑郁症患者（DP）在住院时进行评估，然后在4.5年、7.5年和10年随访时进行重新评估。SZ/SZAF患者在阴性症状的频率和持续时间方面与DP患者有显著差异，但与OP组无显著差异。在任何诊断组中，阴性症状与抑郁症无关。在SZ/SZAF组中，常规抗精神病药物的剂量（而非简单使用）与症状的严重程度相关。尽管与DP患者相比，SZ/SZAF受试者的阴性症状通常最严重且最常见，但OP组和SZ/SZAF组之间的阴性症状现象学几乎没有统计学显著差异。这些数据与一个模型相一致，该模型将阴性症状识别为一般精神疾病的常见症状，在精神病中的发病率特别高。
This study assessed differences in negative symptom presentation between schizophrenia/schizoaffective, other psychotic, and depressed patients over a 10-year followup period. One hundred fifty individuals with schizophrenia or schizoaffective disorders (SZ/SZAF), other psychotic disorders (OP), and depressed patients (DP) were assessed at index hospitalization, then reassessed at 4.5-year, 7.5-year, and 10-year followups. SZ/SZAF patients significantly differed from DP patients in frequency and persistence of negative symptoms but were not significantly different from the OP group. Negative symptoms were not associated with depression in any diagnostic group. Dosage, but not simple use, of conventional antipsychotic medications was related to severity of symptoms in the SZ/SZAF group. Although negative symptoms were typically most severe and most common in the SZ/SZAF subjects in comparison to the DP patients, there were few statistically significant differences in the phenomenology of negative symptoms between the OP and SZ/SZAF groups. The data are consistent with a model that identifies negative symptoms as common to mental illnesses generally, with particularly high rates in psychotic illnesses.