Normal conditioned inhibition and extinction of freezing and fear-potentiated startle following electrolytic lesions of medial prefrontal cortex in rats
Normal conditioned inhibition and extinction of freezing and fear-potentiated startle following electrolytic lesions of medial prefrontal cortex in rats
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DOI：
10.1037/0735-7044.111.4.712
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发表时间：
1997-08-01
影响因子：
1.9
通讯作者：
Davis, M
中科院分区：
文献类型：
--
作者：
Gewirtz, JC;Falls, WA;Davis, M
采用巴甫洛夫消失和条件抑制两种模式，研究了大鼠内侧前额叶皮层（mPFC）在条件恐惧抑制中的作用。在实验1中，腹侧mPFC的损伤不干扰恐惧增强惊吓反应的条件抑制。在实验2中，习得恐惧条件反射后产生的损伤不会阻碍恐惧对视觉条件刺激（CS）的消退，也不会损害在无信号呈现非条件刺激后恐惧的“恢复”。在实验3中，在恐惧条件反射之前做出的损伤并没有延缓恐惧增强的惊吓或对听觉CS的冻结的消退。在实验2和实验3中，情境线索对恐惧的消除也不受；病变。这些结果表明，腹侧mPFC在各种情况下对恐惧的抑制不是必需的。
The authors investigated the role of medial prefrontal cortex (mPFC) in the inhibition of conditioned fear in rats using both Pavlovian extinction and conditioned inhibition paradigms. In Experiment 1, lesions of ventral mPFC did not interfere with conditioned inhibition of the fear-potentiated startle response. In Experiment 2, lesions made after acquisition of fear conditioning did not retard extinction of fear to a visual conditioned stimulus (CS) and did not impair ''reinstatement'' of fear after unsignaled presentations of the unconditioned stimulus. In Experiment 3, lesions made before fear conditioning did not retard extinction of fear-potentiated startle or freezing to an auditory CS. In both Experiments 2 and 3, extinction of fear to contextual cues was also unaffected by; the lesions. These results indicate that ventral mPFC is not essential for the inhibition of fear under a variety of circumstances.