Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits.
Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits.
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DOI：
10.1016/j.cell.2016.01.027
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发表时间：
2016-03-24
期刊：
影响因子：
64.5
通讯作者：
Jessell TM
中科院分区：
文献类型：
--
作者：
Bikoff JB;Gabitto MI;Rivard AF;Drobac E;Machado TA;Miri A;Brenner-Morton S;Famojure E;Diaz C;Alvarez FJ;Mentis GZ;Jessell TM
动物通过参与指导肌肉收缩精确序列的脊髓回路来产生运动，但位于这些回路核心的局部中间神经元的身份和组织逻辑仍未得到解决。在这里，我们展示了V1中间神经元，一个主要的抑制群体，控制运动输出，在19个转录因子表达的基础上分成高度不同的亚群。转录定义的V1亚群表现出明显的生理特征和高度结构化的空间分布，具有中外侧和背腹侧位置偏倚。这些位置的区别限制了来自感觉神经元和运动神经元的输入模式，认为中间神经元的位置是微电路组织的决定因素。此外，V1多样性表明，控制髋关节、踝关节和足部肌肉的运动池存在不同的抑制性微电路，揭示了控制肢体运动的中间神经元的可变电路结构。
Animals generate movement by engaging spinal circuits that direct precise sequences of muscle contraction, but the identity and organizational logic of local interneurons that lie at the core of these circuits remain unresolved. Here we show that V1 interneurons, a major inhibitory population that controls motor output, fractionate into highly diverse subsets on the basis of the expression of nineteen transcription factors. Transcriptionally defined V1 subsets exhibit distinct physiological signatures and highly structured spatial distributions with mediolateral and dorsoventral positional biases. These positional distinctions constrain patterns of input from sensory and motor neurons, arguing that interneuron position is a determinant of microcircuit organization. Moreover, V1 diversity indicates that different inhibitory microcircuits exist for motor pools controlling hip, ankle, and foot muscles, revealing a variable circuit architecture for interneurons that control limb movement.