Tissue engineering.
Tissue engineering.
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DOI：
10.1515/iupac.84.0180
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发表时间：
1998
影响因子：
2.3
通讯作者：
M. Vert;Y. Doi;K. Hellwich;Michael Hess;Philip Hodge;P. Kubisa;M. Rinaudo;F. Schué
中科院分区：
文献类型：
--
作者：
M. Vert;Y. Doi;K. Hellwich;Michael Hess;Philip Hodge;P. Kubisa;M. Rinaudo;F. Schué
伤口护理已经成为最先看到一种新技术的好处的领域之一：组织工程。组织工程涉及能够与生物组织特异性相互作用的新材料或装置的开发。在伤口护理中，这些材料可以完全基于天然存在的组织和细胞，或者可以是将联合收割机合成物（通常为聚合物）与生物层结合的材料。伤口敷料和皮肤替代品都有供应。材料的复杂性取决于最终用途。一般来说，由聚合物材料制成的合成材料（如Tegadalone和Opsite）用作相对简单和浅伤口的伤口敷料，或用作更复杂敷料的覆盖物。它们的功能是防止水分流失、干燥和机械损伤。更复杂的敷料从由重组胶原蛋白和硫酸软骨素制成的真皮替代物，由聚合物层（如Integra）支撑，到含有胶原蛋白和接种细胞的复合Apligraf商标。这最后被设计为一个完整的皮肤替代品或皮肤替代品。最终，工程皮肤将包含调节愈合所需的所有组件并提供所需的反应：用有限的疤痕组织闭合伤口，保留天然皮肤的所有特征。
Wound care has become one of the first fields to see the benefit of a new technology: tissue engineering. Tissue engineering involves the development of new materials or devices capable of specific interactions with biological tissues. In wound care, these materials may be based entirely on naturally occurring tissues and cells, or may be materials that combine synthetics, usually polymers, with biological layers. Both wound dressings and skin substitutes are available. The complexity of the materials depends on the end uses. Generally, synthetics made from polymeric materials such as Tegaderm and Opsite are used as wound dressings over relatively simple and shallow wounds or as coverings over more complex dressings. Their function is one of protection from water loss, drying, and mechanical injury. More complex dressings vary from dermal replacements made of reconstituted collagen and chondroitan sulfate backed by a polymer layer such as Integra(R) to the complex Apligraftrade mark that contains collagen and seeded cells. This last is designed as a complete skin replacement or skin substitute. Ultimately, engineered skin will contain all of the components necessary to modulate healing and provide the desired response: a wound closed with limited scar tissue that retains all of the characteristics of natural skin.