Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.
Long-term complete response in a patient with disseminated pulmonary pleomorphic carcinoma induced by cisplatin and gemcitabine.
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DOI：
10.2169/internalmedicine.53.2637
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发表时间：
2014
影响因子：
1.2
通讯作者：
A. Tamiya;K. Asami;S. Shimizu;A. Matsumura;S. Isa;K. Okishio;M. Kitaichi;S. Atagi;M. Takada;T. Kawaguchi;A. Kubo
中科院分区：
文献类型：
--
作者：
A. Tamiya;K. Asami;S. Shimizu;A. Matsumura;S. Isa;K. Okishio;M. Kitaichi;S. Atagi;M. Takada;T. Kawaguchi;A. Kubo
一位47岁的男性患者在接受肺多形性癌根治性手术6周后，因肺、肝多发转移伴胸膜播散而转介至我科。他接受了两种化疗方案，两种方案都导致疾病进展。考虑到患者一般情况良好，给予顺铂加吉西他滨（GP）治疗。在6个疗程的GP治疗后，转移性病变表现出完全缓解，并且患者在6年多的时间里没有复发。免疫组化分析显示肿瘤高表达吉西他滨转运蛋白人平衡核苷转运蛋白1，提示肿瘤对吉西他滨具有高敏感性。
A 47-year-old man was referred to our department due to multiple metastases in the lungs and liver with pleural dissemination six weeks after undergoing curative surgery for lung pleomorphic carcinoma. He received two regimens of chemotherapy, both of which resulted in disease progression. Considering his good general condition, he was treated with cisplatin plus gemcitabine (GP). The metastatic lesions exhibited a complete response after six courses of GP, and the patient has remained free from recurrence for over six years. An immunohistochemical analysis revealed that the tumor was highly expressive of gemcitabine transporter human equilibrative nucleoside transporter 1, thus suggesting a high sensitivity to gemcitabine.