Allergic Inflammation - Innately Homeostatic
Allergic Inflammation - Innately Homeostatic
复制标题
DOI：
10.1101/cshperspect.a016352
复制
发表时间：
2015-03-01
影响因子：
7.2
通讯作者：
Locksley, Richard M.
中科院分区：
文献类型：
--
作者：
Cheng, Laurence E.;Locksley, Richard M.
过敏性炎症与寄生虫感染密切相关，但也与哮喘和其他常见的过敏性疾病密切相关。尽管参与了类似的免疫途径，寄生虫感染的个体往往没有表现出过敏性疾病的外在表现。从这个角度来看，我们提出的论文，过敏性炎症反应在调节昼夜节律和环境输入参与组织稳态和代谢的需要发挥主要作用。寄生虫进入这些途径，从而参与过敏性炎症，以维持寄生虫生命周期的各个方面。在对寄生虫感染的应答中，适应性和调节性免疫应答在宿主效应物应答上分层，但在变态反应的情况下，效应物应答保持不受调节，从而导致疾病的主要特征。进一步了解驱动过敏性炎症的稳态压力有望进一步了解人类健康和这些常见疾病的治疗。
Allergic inflammation is associated closely with parasite infection but also asthma and other common allergic diseases. Despite the engagement of similar immunologic pathways, parasitized individuals often show no outward manifestations of allergic disease. In this perspective, we present the thesis that allergic inflammatory responses play a primary role in regulating circadian and environmental inputs involved with tissue homeostasis and metabolic needs. Parasites feed into these pathways and thus engage allergic inflammation to sustain aspects of the parasitic life cycle. In response to parasite infection, an adaptive and regulated immune response is layered on the host effector response, but in the setting of allergy, the effector response remains unregulated, thus leading to the cardinal features of disease. Further understanding of the homeostatic pressures driving allergic inflammation holds promise to further our understanding of human health and the treatment of these common afflictions.