Beta-blockers reduced the risk of cardiac rupture in patients with acute myocardial infarction: A meta-analysis of randomized control trials
Beta-blockers reduced the risk of cardiac rupture in patients with acute myocardial infarction: A meta-analysis of randomized control trials
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β-受体阻滞剂可降低急性心肌梗死患者心脏破裂的风险：随机对照试验的荟萃分析
DOI：
10.1016/j.ijcard.2017.01.035
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发表时间：
2017-04-01
影响因子：
3.5
通讯作者：
Nie, Shao-ping
中科院分区：
文献类型：
--
作者：
Gong, Wei;Feng, Siting;Nie, Shao-ping
背景资料：心脏破裂（CR）是急性心肌梗死（MI）后发生的灾难性并发症，目前还没有有效的药理学策略来预防这种情况。本荟萃分析的目的是评估β受体阻滞剂对急性MI患者CR的影响。方法：广泛检索PUBMED、EMBASE、ISI Web of Science、MEDLINE和科克伦，检索β受体阻滞剂治疗急性MI患者的研究。使用随机效应模型合并数据。结果：共纳入4项随机对照试验，共纳入68842例患者，其中603例患者达到完全缓解。Meta分析显示，β受体阻滞剂导致CR发生率降低32%，具有统计学和临床意义（RR：0.68，95% CI：0.47至0.99，P= 0.04）。这项荟萃分析的结果证实，早期使用β受体阻滞剂与CR发生率降低相关，提示β-受体阻滞剂对急性MI后梗死愈合的某些有益作用。(C)2017爱思唯尔爱尔兰有限公司版权所有。
Background: Cardiac rupture (CR) is a catastrophic complication that occurs after acute myocardial infarction (MI) and, at present, there are no effective pharmacological strategies for preventing this condition. The objective of this meta-analysis was to assess the effect of beta-blockers on CR in patients with acute MI.Methods: An extensive search of the PUBMED, EMBASE, ISI Web of Science, MEDLINE and Cochrane was performed to retrieve the studies of beta-blockers treatment in patients with acute MI. Data were combined using a random effects model. A meta-analysis was performed using Review Manager 5.3.Results: Four randomized controlled trials (RCTs) involving 68, 842 patients, 603 of whom occurred CR, were met criteria. Meta analysis showed that beta-blockers caused a statistically and clinically significant decrease in the incidence of CR of 32% (RR: 0.68, 95% CI: 0.47 to 0.99, P= 0.04).Conclusions: The findings of this meta-analysis confirmed that the early use of beta-blockers is associated with decreased incidence of CR, suggesting some beneficial effects of beta-blockers on infarct healing after acute MI. (C) 2017 Elsevier Ireland Ltd. All rights reserved.