Identification and characterization of an Egr ortholog as a neural immediate early gene in the European honeybee (Apis mellifera L.)
Identification and characterization of an Egr ortholog as a neural immediate early gene in the European honeybee (Apis mellifera L.)
复制标题
欧洲蜜蜂 (Apis mellifera L.) 神经立即早期基因 Egr 直系同源物的鉴定和表征
DOI：
10.1016/j.febslet.2013.08.014
复制
发表时间：
2013
期刊：
影响因子：
3.5
通讯作者：
Takeo Kubo
中科院分区：
文献类型：
--
作者：
Atsushi Ugajin;Takekazu Kunieda;Takeo Kubo
到目前为止，关于昆虫中存在即刻早期基因(IEG)的报道很少。为了识别昆虫中保守的IEG，我们描述了蜜蜂的一个Egr同源基因(AmEgr：ApismelvenaEgr)。在癫痫诱导后，AMEgris在整个工蜂大脑中瞬时诱导。在AmEgri杂交的情况下，某个蘑菇体(较高大脑中心)神经元亚型的神经活性与我们之前使用另一个非编码IEG Termedkakusei鉴定的相同，在觅食脑中更强。这些发现表明，Egrs可以作为昆虫的IEG。
To date, there are only few reports of immediate early genes (IEGs) available in insects. Aiming at identifying a conserved IEG in insects, we characterized anEgrhomolog of the honeybee (AmEgr:ApismelliferaEgr).AmEgrwas transiently induced in whole worker brains after seizure induction.In situhybridization forAmEgrindicated that neural activity of a certain mushroom body (a higher brain center) neuron subtype, which is the same as that we previously identified using another non-coding IEG, termedkakusei, is more enhanced in forager brains. These findings suggest thatEgrcan be utilized as an IEG in insects.